Document Detail

Migrating focal seizures during infancy: a case report and pathologic study.
MedLine Citation:
PMID:  22353295     Owner:  NLM     Status:  MEDLINE    
Migrating focal seizures in infancy are an unusual and often overlooked epilepsy syndrome, with onset before age 6 months, in which nearly continuous seizures involve multiple, independent areas of both hemispheres with an arrest of psychomotor development. We describe a patient with migrating focal seizures in infancy whose seizures began at age 45 days. The seizures were refractory to common antiepileptic drugs. At age 6 months, the infant received potassium bromide and became almost seizure-free. The infant developed severe neurologic impairment, with marked axial hypotonia and an absence of visual contact and head control. At age 8 months, the child suddenly died. Pathologic findings included multiple malformations of cortical development, polymicrogyria, and focal cortical dysplasia associated with hippocampal sclerosis.
Lorena Fasulo; Silvia Saucedo; Lidia Cáceres; Silvana Solis; Roberto Caraballo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  46     ISSN:  1873-5150     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-22     Completed Date:  2012-07-05     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  182-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Neuropediatrics, Prof. Dr. A. Posadas Hospital, Buenos Aires, Argentina.
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MeSH Terms
Cerebral Cortex / abnormalities*,  pathology
Disease Progression
Epilepsies, Partial / pathology*
Fatal Outcome
Malformations of Cortical Development / pathology*
Comment In:
Pediatr Neurol. 2012 Sep;47(3):229; author reply 229-30   [PMID:  22883298 ]

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