Document Detail

Migraines linked to intrapulmonary right-to-left shunt.
MedLine Citation:
PMID:  16618261     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if there is an association between migraines and intrapulmonary right-to-left shunt. BACKGROUND: Several studies have described an association between migraines and intracardiac right-to-left shunt. METHODS: Patients with hereditary hemorrhagic telangiectasia (HHT) were retrospectively recruited from the Toronto Hereditary Hemorrhagic Telangiectasia Center Clinical Database. All patients had been prospectively, systematically asked about a history of migraines and systematically screened for pulmonary and cerebral arteriovenous malformations (AVMs). All patients with a definite diagnosis of HHT, assessed during a 2-year period (February 1997 to April 1999), were included. Univariate analyses and logistic regression were performed, for migraine as the dependent variable and the following independent variables: age, sex, pulmonary AVMs, and cerebral AVMs. RESULTS: Of the 200 patients assessed during the 2-year period, 124 (62%) had a definite diagnosis of HHT and were included in the analysis. Eighty (65%) were females. Forty-seven (38%) of the HHT patients had a history of migraine, of whom 38 (81%) had migraine with aura. The prevalence of migraine was greater in patients with pulmonary AVMs (46%) compared to patients without pulmonary AVMs (33%), OR = 1.7 (0.8 to 3.6), though this did not reach statistical significance (P = .14). Pulmonary AVMs were significantly associated with migraine (OR = 2.4, 95% CI = 1.1 to 5.5, P = .04), after adjustment for age and sex, using logistic regression. CONCLUSIONS: There is a significant association between intrapulmonary right-to-left shunt and migraine.
John Thenganatt; Jacob Schneiderman; Robert H Hyland; John Edmeads; Jennifer L Mandzia; Marie E Faughnan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Headache     Volume:  46     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2006-07-26     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-43     Citation Subset:  IM    
Division of Respirology, Department of Medicine, St. Michael's Hospital, University of Toronto, ON, Canada.
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MeSH Terms
Arteriovenous Malformations / complications*
Intracranial Arteriovenous Malformations / complications
Lung Diseases / complications*
Migraine Disorders / etiology*
Prospective Studies
Retrospective Studies
Telangiectasia, Hereditary Hemorrhagic / complications*

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