| Migraines linked to intrapulmonary right-to-left shunt. | |
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MedLine Citation:
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PMID: 16618261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine if there is an association between migraines and intrapulmonary right-to-left shunt. BACKGROUND: Several studies have described an association between migraines and intracardiac right-to-left shunt. METHODS: Patients with hereditary hemorrhagic telangiectasia (HHT) were retrospectively recruited from the Toronto Hereditary Hemorrhagic Telangiectasia Center Clinical Database. All patients had been prospectively, systematically asked about a history of migraines and systematically screened for pulmonary and cerebral arteriovenous malformations (AVMs). All patients with a definite diagnosis of HHT, assessed during a 2-year period (February 1997 to April 1999), were included. Univariate analyses and logistic regression were performed, for migraine as the dependent variable and the following independent variables: age, sex, pulmonary AVMs, and cerebral AVMs. RESULTS: Of the 200 patients assessed during the 2-year period, 124 (62%) had a definite diagnosis of HHT and were included in the analysis. Eighty (65%) were females. Forty-seven (38%) of the HHT patients had a history of migraine, of whom 38 (81%) had migraine with aura. The prevalence of migraine was greater in patients with pulmonary AVMs (46%) compared to patients without pulmonary AVMs (33%), OR = 1.7 (0.8 to 3.6), though this did not reach statistical significance (P = .14). Pulmonary AVMs were significantly associated with migraine (OR = 2.4, 95% CI = 1.1 to 5.5, P = .04), after adjustment for age and sex, using logistic regression. CONCLUSIONS: There is a significant association between intrapulmonary right-to-left shunt and migraine. |
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Authors:
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John Thenganatt; Jacob Schneiderman; Robert H Hyland; John Edmeads; Jennifer L Mandzia; Marie E Faughnan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Headache Volume: 46 ISSN: 0017-8748 ISO Abbreviation: Headache Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-04-18 Completed Date: 2006-07-26 Revised Date: 2009-02-02 |
Medline Journal Info:
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Nlm Unique ID: 2985091R Medline TA: Headache Country: United States |
Other Details:
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Languages: eng Pagination: 439-43 Citation Subset: IM |
Affiliation:
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Division of Respirology, Department of Medicine, St. Michael's Hospital, University of Toronto, ON, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteriovenous Malformations
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complications* Female Humans Intracranial Arteriovenous Malformations / complications Lung Diseases / complications* Male Migraine Disorders / etiology* Prospective Studies Retrospective Studies Telangiectasia, Hereditary Hemorrhagic / complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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