Document Detail

Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study.
MedLine Citation:
PMID:  20736269     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate whether migraine in mid-life is associated with mortality from cardiovascular disease, other causes, and all causes.
DESIGN: Population based cohort study.
SETTING: Reykjavik, Iceland.
PARTICIPANTS: 18,725 men and women, born 1907-35 and living in Reykjavik and adjacent communities.
MAIN OUTCOME MEASURES: Mortality from cardiovascular disease, non-cardiovascular disease, and all causes. Questionnaires and clinical measures were obtained in mid-life (mean age 53, range 33-81) in the Reykjavik Study (1967-91). Headache was classified as migraine without aura, migraine with aura, or non-migraine headache. Median follow-up was 25.9 years (0.1-40.2 years), with 470,990 person years and 10,358 deaths: 4323 from cardiovascular disease and 6035 from other causes. We used Cox regression to estimate risk of death in those with migraine compared with others, after adjusting for baseline risk factors.
RESULTS: People with migraine with aura were at increased risk of all cause mortality (adjusted (for sex and multivariables) hazard ratio 1.21, 95% confidence interval 1.12 to 1.30) and mortality from cardiovascular disease (1.27, 1.13 to 1.43) compared with people with no headache, while those with migraine without aura and non-migraine headache were not. Further examination of mortality from cardiovascular disease shows that people with migraine with aura were at increased risk of mortality from coronary heart disease (1.28, 1.11 to 1.49) and stroke (1.40, 1.10 to 1.78). Women with migraine with aura were also at increased risk of mortality from non-cardiovascular disease (1.19, 1.06 to 1.35).
CONCLUSIONS: Migraine with aura is an independent risk factor for cardiovascular and all cause mortality in men and women. The risk of mortality from coronary heart disease and stroke mortality is modestly increased in people with migraine, particularly those with aura.
Larus S Gudmundsson; Ann I Scher; Thor Aspelund; Jon H Eliasson; Magnus Johannsson; Gudmundur Thorgeirsson; Lenore Launer; Vilmundur Gudnason
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-24
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  341     ISSN:  1756-1833     ISO Abbreviation:  BMJ     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-25     Completed Date:  2010-09-23     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  England    
Other Details:
Languages:  eng     Pagination:  c3966     Citation Subset:  AIM; IM    
Department of Pharmacology and Toxicology, University of Iceland, Hagi Hofsvallagata 53, IS-107 Reykjavik, Iceland.
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MeSH Terms
Aged, 80 and over
Cardiovascular Diseases / mortality*
Cause of Death
Iceland / epidemiology
Middle Aged
Migraine with Aura / mortality*
Prospective Studies
Risk Factors
Sex Distribution
Comment In:
Evid Based Med. 2011 Apr;16(2):60-2   [PMID:  21252164 ]
BMJ. 2010;341:c4410   [PMID:  20736272 ]

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