Document Detail

Migraine and prothrombotic genetic risk factors.
MedLine Citation:
PMID:  9673804     Owner:  NLM     Status:  MEDLINE    
It has been suggested that during attacks of migraine both platelet activation and plasma coagulability are increased. We investigated the prevalence of several prothrombotic genetic risk factors in patients with migraine: factor V R/Q 506, factor II 20210 G/A, decanucleotide insertion/deletion in the factor VII promoter, and the platelet HPA-1 and HPA-2 alloantigenic systems, by genotypic identification in an age- and sex-matched case-control study including 106 patients with migraine (49 with aura, and 57 without aura). The prevalence of all genotypes was similar among case patients and controls. No association in relation to the type of migraine was detected in the factor II, factor VII, HPA-1, or HPA-2 polymorphisms. Our results showed a high prevalence of factor V Leiden in those patients with migraine with aura (6.1%), though that association was not statistically significant. The studied prothrombotic genetic factors do not seem to be associated with the development of migraine and, therefore, are not likely relevant in the previously reported hypercoagulability and platelet hyperaggregability in this disease.
J Corral; J A Iniesta; R González-Conejero; M L Lozano; J Rivera; V Vicente
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  18     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-22     Completed Date:  1998-09-22     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
Unit of Hematology and Neurology, University General Hospital, Murcia, Spain.
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MeSH Terms
Blood Coagulation Factors / genetics*
Middle Aged
Migraine Disorders / blood,  genetics*
Polymerase Chain Reaction
Polymorphism, Genetic
Risk Factors
Reg. No./Substance:
0/Blood Coagulation Factors

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