| Migraine and prothrombotic genetic risk factors. | |
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MedLine Citation:
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PMID: 9673804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that during attacks of migraine both platelet activation and plasma coagulability are increased. We investigated the prevalence of several prothrombotic genetic risk factors in patients with migraine: factor V R/Q 506, factor II 20210 G/A, decanucleotide insertion/deletion in the factor VII promoter, and the platelet HPA-1 and HPA-2 alloantigenic systems, by genotypic identification in an age- and sex-matched case-control study including 106 patients with migraine (49 with aura, and 57 without aura). The prevalence of all genotypes was similar among case patients and controls. No association in relation to the type of migraine was detected in the factor II, factor VII, HPA-1, or HPA-2 polymorphisms. Our results showed a high prevalence of factor V Leiden in those patients with migraine with aura (6.1%), though that association was not statistically significant. The studied prothrombotic genetic factors do not seem to be associated with the development of migraine and, therefore, are not likely relevant in the previously reported hypercoagulability and platelet hyperaggregability in this disease. |
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Authors:
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J Corral; J A Iniesta; R González-Conejero; M L Lozano; J Rivera; V Vicente |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: 18 ISSN: 0333-1024 ISO Abbreviation: Cephalalgia Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-09-22 Completed Date: 1998-09-22 Revised Date: 2008-02-11 |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: NORWAY |
Other Details:
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Languages: eng Pagination: 257-60 Citation Subset: IM |
Affiliation:
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Unit of Hematology and Neurology, University General Hospital, Murcia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Coagulation Factors / genetics* Female Genotype Humans Male Middle Aged Migraine Disorders / blood, genetics* Polymerase Chain Reaction Polymorphism, Genetic Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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