| Migraine and motion sickness: what is the link? | |
| | |
MedLine Citation:
|
PMID: 20416353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The brainstem is a structurally complex region, containing numerous ascending and descending fibres that converge on centres that regulate bodily functions essential to life. Afferent input from the cranial tissues and the special senses is processed, in part, in brainstem nuclei. In addition, brainstem centres modulate the flow of pain messages and other forms of sensory information to higher regions of the brain, and influence the general excitability of these cortical regions. Thus, disruptions in brainstem processing might evoke a complex range of unpleasant symptoms, vegetative changes and neurovascular disturbances and that, together, form attacks of migraine. Migraine is linked with various co-morbid conditions, the most prominent being motion sickness. Symptoms such as nausea, dizziness and headache are common to motion sickness and migraine; moreover, migraine sufferers have a heightened vulnerability to motion sickness. As both maladies involve reflexes that relay in the brainstem, symptoms may share the same neural circuitry. In consequence, subclinical interictal persistence of disturbances in these brainstem pathways could not only increase vulnerability to recurrent attacks of migraine but also increase susceptibility to motion sickness. Mechanisms that mediate symptoms of motion sickness and migraine are explored in this paper. The physiology of motion sickness and migraine is discussed, and neurotransmitters that may be involved in the manifestation of symptoms are reviewed. Recent findings have shed light on the relationship between migraine and motion sickness, and provide insights into the generation of migraine attacks. |
| | |
Authors:
|
Anna Cuomo-Granston; Peter D Drummond |
Related Documents
:
|
15640383 - Mechanical deformation of neutrophils into narrow channels induces pseudopod projection... 8742023 - Motion sickness during off-vertical axis rotation: prediction by a model of sensory int... 11744683 - A neural clockwork for encoding circadian time. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-21 |
Journal Detail:
|
Title: Progress in neurobiology Volume: 91 ISSN: 1873-5118 ISO Abbreviation: Prog. Neurobiol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-05 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370121 Medline TA: Prog Neurobiol Country: England |
Other Details:
|
Languages: eng Pagination: 300-12 Citation Subset: IM |
Copyright Information:
|
(c) 2010. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Faculty of Health Sciences: School of Psychology, Murdoch University, 6150, Western Australia, Australia. a.cgranston@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain Stem / physiopathology Gastrointestinal Diseases / complications Humans Hypothalamus / physiopathology Migraine Disorders / complications*, pathology Motion Sickness / complications*, pathology Serotonin / metabolism Vascular Diseases / complications Vestibular Diseases / complications |
| Chemical | |
Reg. No./Substance:
|
50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: D-serine enhances extinction of auditory cued fear conditioning via ERK1/2 phosphorylation in mice.
Next Document: Depressed mood and emotional responding.