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Migraine in cervical artery dissection and ischemic stroke patients.
MedLine Citation:
PMID:  22491867     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:Several small to medium-sized studies indicated a link between cervical artery dissection (CeAD) and migraine. Migrainous CeAD patients were suggested to have different clinical characteristics compared to nonmigraine CeAD patients. We tested these hypotheses in the large Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) population. METHODS:A total of 968 CeAD patients and 653 patients with an ischemic stroke of a cause other than CeAD (non-CeAD IS) were recruited. CeAD patients with stroke (CeAD(stroke), n = 635) were compared with non-CeAD IS patients regarding migraine, clinical characteristics, and outcome. CeAD patients with and without migraine were compared in terms of clinical characteristics and outcome. RESULTS:Migraine was more common among CeAD(stroke) patients compared to non-CeAD IS patients (35.7 vs 27.4%, p = 0.003). The difference was mainly due to migraine without aura (20.2 vs 11.2%, p < 0.001). There were no differences in prevalence of strokes, arterial distribution, or other clinical or prognostic features between migrainous and nonmigrainous CeAD patients. CONCLUSION:Migraine without aura is more common among CeAD(stroke) patients compared to non-CeAD IS patients. The mechanisms and possible causative link remain to be proved. Although CeAD is often complicated by stroke, our data do not support increased risk of stroke in migrainous CeAD patients.
Authors:
T M Metso; T Tatlisumak; S Debette; J Dallongeville; S T Engelter; P A Lyrer; V Thijs; A Bersano; S Abboud; D Leys; C Grond-Ginsbach; M Kloss; E Touzé; A Pezzini; A J Metso;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Neurology (T.M.M., T.T., A.J.M.), Helsinki University Central Hospital, Helsinki, Finland; Department of Epidemiology and Public Health (S.D., J.D.), Inserm U744, Pasteur Institute, Université Lille Nord de France, Lille; Department of Neurology (S.D., D.L.), EA2691/EA1046, Lille University Hospital, Lille; Department of Epidemiology (S.D.), Paris Ile-de-France Ouest School of Medicine, University of Versailles Saint-Quentin en Yvelines, France; Department of Neurology (S.T.E., P.A.L.), Basel University Hospital, Switzerland; Vesalius Research Center (V.T.), VIB, and Department of Neurology, Leuven University Hospitals, Leuven, Belgium; U.O. Neurologia (A.B.), Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy; Laboratory of Experimental Neurology ULB (S.A.), Brussels, Belgium; Department of Neurology (C.G.-G., M.K.), Heidelberg University Hospital, Heidelberg, Germany; Department of Neurology (E.T.), Hôpital Sainte-Anne, Université Paris Descartes, INSERM UMS S894, Paris, France; and Department of Medical and Surgical Sciences (A.P.), Neurology Clinic, University of Brescia, Italy.
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