| Migraine is frequent in patients with systemic lupus erythematosus: A case-control study. | |
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MedLine Citation:
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PMID: 20974597 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: The objective of this study was to compare the prevalence of primary headaches in systemic lupus erythematosus (SLE) versus healthy subjects, and to determine whether headaches in SLE are associated with MRI- or cerebrospinal fluid (CSF) abnormalitites. Patients and methods: The case-control study included MRI- and CSF investigations. Headache was classified according to the International Classification of Headache Disorders. Depression and fatigue were measured with Beck Depression Inventory (BDI) and Fatigue Severity Scale (FSS) respectively. Results: Twenty-four out of 67 SLE patients and 13 out of 67 age- and gender matched healthy subjects had migraine (36% vs 19%, P = 0.03). Nine (13%) SLE patients had migraine with aura vs 4 (6%) in healthy subjects, P = 0.14. The prevalence of tension type headache was equal (60% in patients vs 58% in controls). There was no association between migraine and SLE disease activity, biochemical or immunological markers, cerebral white matter hyperintensities, interleukin-6 in CSF, impairment of the blood-brain barrier, or intrathecal immunoglobulin production. SLE patients had higher BDI- and FSS scores compared with healthy control subjects, and SLE patients with migraine had higher BDI scores than lupus patients without migraine. Conclusions: Migraine is more prevalent in SLE patients, associated with depression like in the general population, but not associated with disease activity or abnormalities detected on cerebral MRI, in CSF, or any SLE characteristics except from SLE photosensitivity. The inclusion of the migraine item in SLE disease activity instruments remains questionable. |
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Authors:
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Anne B Tjensvoll; Erna Harboe; Lasse G Gøransson; Mona K Beyer; Ole J Greve; Anita Herigstad; Jan T Kvaløy; Roald Omdal |
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Publication Detail:
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Type: Journal Article Date: 2010-06-07 |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: 31 ISSN: 1468-2982 ISO Abbreviation: Cephalalgia Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: England |
Other Details:
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Languages: eng Pagination: 401-8 Citation Subset: IM |
Affiliation:
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Stavanger University Hospital, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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