| Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course. | |
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MedLine Citation:
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PMID: 20625916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objectives of this study were: (1) to assess relative frequency of migraine in multiple sclerosis (MS) patients using the validated self-administered diagnostic questionnaire, and to compare the migraine rates in MS outpatients to age- and gender-matched historical population controls; (2) to compare clinical and radiographic characteristics in MS patients with migraine and headache-free MS patients. We conducted a cross-sectional study to assess the demographic profiles, headache features and clinical characteristics of MS patients attending a MS clinic using a questionnaire based on the American Migraine Prevalence and Prevention (AMPP) study. We compared the relative frequency of migraine in MS clinic patients and AMPP cohort. We also compared clinical and radiographic features in MS patients with migraine to an MS control group without headache. Among 204 MS patients, the relative frequency of migraine was threefold higher than in population controls both for women [55.7 vs. 17.1%; prevalence ratio (PR) =3.26, p<0.001] and men (18.4 vs. 5.6%; PR=3.29, p<0.001). In a series of logistic regression models that controlled for age, gender, disease duration, β-interferon use, and depression, migraine in MS patients was significantly associated (p<0.01) with trigeminal and occipital neuralgia, facial pain, Lhermitte's sign, temporomandibular joint pain, non-headache pain and a past history of depression. Migraine status was not significantly associated with disability on patient-derived disability steps scale or T2 lesion burden on brain MRI. Migraine is three-times more common in MS clinic patients than in general population. MS-migraine group was more symptomatic than the MS-no headache group. |
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Authors:
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Ilya Kister; A B Caminero; T S Monteith; A Soliman; T E Bacon; J H Bacon; J T Kalina; M Inglese; J Herbert; R B Lipton |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-13 |
Journal Detail:
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Title: The journal of headache and pain Volume: 11 ISSN: 1129-2377 ISO Abbreviation: J Headache Pain Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100940562 Medline TA: J Headache Pain Country: Italy |
Other Details:
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Languages: eng Pagination: 417-25 Citation Subset: IM |
Affiliation:
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Department of Neurology, NYU-MS Care Center, NYU School of Medicine, 301 E 17th St., New York, NY 10003, USA. ilya.kister@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Comorbidity Cross-Sectional Studies Female Humans Immunologic Factors / therapeutic use Interferon-beta / therapeutic use Magnetic Resonance Imaging / methods Male Middle Aged Migraine Disorders / complications*, diagnosis, physiopathology* Multiple Sclerosis / complications*, diagnosis, drug therapy, physiopathology* Nervous System Diseases / etiology Pain Measurement Predictive Value of Tests |
| Grant Support | |
ID/Acronym/Agency:
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K23AG030857/AG/NIA NIH HHS; K23NS051409-01A1/NS/NINDS NIH HHS; K23NS47256/NS/NINDS NIH HHS; P01 AG03949/AG/NIA NIH HHS; P01AG027734/AG/NIA NIH HHS; R01AG025119/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors; 77238-31-4/Interferon-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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