Document Detail


Might analysis, synthesis and metabolism of CLA contribute to explain the biological effects of CLA?
MedLine Citation:
PMID:  12915331     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conjugated Linoleic Acids (CLA) are of great interest for analysts since techniques have been developed to determine the dietary occurrence of CLA with a good accuracy. CLA is found in animal products from ruminant sources as the result of biohydrogenation of polyunsaturated fatty acids in the rumen and as the consequence of the delta-9 desaturation of vaccenic acid in animal tissues. CLA can also be obtained in the laboratory by isomerisation of linoleic acid or by total chemical synthesis. While the "natural" isomer is rumenic acid (9c,11t-18:2), synthetic mixtures contain mainly two isomers: the 9c,11t- and the 10t,12c-18:2. Although CLA have been shown to be metabolized into desaturated and chain elongated products, it remains unclear whether these so-formed conjugated metabolites may be involved in the effects of CLA on fatty acid metabolism. Experiments carried out on animal models with CLA have shown different health benefits: anticarcinogenic, antiatherosclerotic effects, modulation of body composition , the "natural" CLA (9c,11t-18:2) being closely related to the protection against cancer and the 10t,12c-18:2 to the reduction of the fat mass. Nevertheless, recent findings have suggested adverse effects in mice. Most of the studies carried out on humans concern the influence of CLA on body composition and its possible inverse association with cancer. Since the results are still controversial and since very few data dealing with the safety of using CLA in long term feeding studies have so far been published, further works are warranted to consider the benefits of CLA for humans.
Authors:
L Bretillon; J L Sébédio; J M Chardigny
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of medical research     Volume:  8     ISSN:  0949-2321     ISO Abbreviation:  Eur. J. Med. Res.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-13     Completed Date:  2004-03-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9517857     Medline TA:  Eur J Med Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  363-9     Citation Subset:  IM    
Affiliation:
National Instiute for Research on Agronomgy, Dijon, France. Lionel.Bretillon@dijon.inra.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriosclerosis / prevention & control*
Body Composition*
Disease Models, Animal
Humans
Linoleic Acid / analysis,  biosynthesis
Linoleic Acids, Conjugated* / analysis,  biosynthesis,  therapeutic use
Neoplasms / prevention & control*
Oleic Acids / analysis,  biosynthesis
Trans Fatty Acids*
Chemical
Reg. No./Substance:
0/Linoleic Acids, Conjugated; 0/Oleic Acids; 0/Trans Fatty Acids; 143-25-9/11-octadecenoic acid; 1839-11-8/9,11-linoleic acid; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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