| Mifepristone versus laminaria: a randomized controlled trial of cervical ripening in midtrimester termination. | |
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MedLine Citation:
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PMID: 17963864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Mifepristone was compared with laminaria for cervical ripening in second-trimester induction of labor (IOL). STUDY DESIGN: We performed a randomized, controlled, open-label study of women undergoing second-trimester IOL for fetal demise, aneuploidy or anomalies at a single tertiary care center from January 2004 to May 2006. Main outcome measures were induction-to-delivery time and pain with cervical ripening. RESULTS: Of 50 eligible women, 37 were enrolled in the study, of whom 33 completed the study: 16 were randomized to laminaria and 17 to mifepristone. Induction-to-delivery time was significantly shorter in the mifepristone arm (mean=10 h vs. 16 h, p=.01; median=7.5 h vs. 13.4 h, p=.01). Pain with cervical ripening was also significantly less in the mifepristone group than in the laminaria group (median=1 vs. 6 on an 11-point visual analogue scale, p<.001). Maternal age, parity, gestational age, fetal demise prior to induction, need for postpartum curettage, blood loss, pain during induction, delivery and at the time of discharge were not significantly different between the two groups. CONCLUSION: Mifepristone shortens the induction-to-delivery time and decreases pain with cervical ripening when compared with laminaria for second-trimester induction. |
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Authors:
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Beth A Prairie; Michele R Lauria; Nathalie Kapp; Todd Mackenzie; Emily R Baker; Karen E George |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2007-10-04 |
Journal Detail:
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Title: Contraception Volume: 76 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-29 Completed Date: 2008-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 383-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. beth.prairie@dartmouth.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00383032 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Steroidal*
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adverse effects Abortion, Induced / methods Adult Cervical Ripening* Female Humans Labor, Induced / methods* Laminaria* Mifepristone* / adverse effects Misoprostol Pain / etiology Pregnancy Pregnancy Trimester, Second Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Steroidal; 59122-46-2/Misoprostol; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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