Document Detail

Mifepristone and prostaglandin for termination of pregnancy: contraindications for use, reasons and rationale.
MedLine Citation:
PMID:  16781254     Owner:  NLM     Status:  MEDLINE    
Drug therapies are usually contraindicated in specific patient populations where evidence suggests that administration may result in a serious reaction or may seriously and negatively alter the risk benefit of treatment. There are few absolute contraindications to licensed regimens of mifepristone and prostaglandin for termination of pregnancy. However, those that are specified on "summary of product characteristics" [product labeling (PL)] differ from country to country. Differences reflect the dynamic environment of emerging scientific evidence, local experience and guidelines, and local regulatory processes, which all influence the resultant PL. The reasons and rationale for specific contraindications for mifepristone and prostaglandin for the termination of pregnancy are detailed, and the reasons for the differences between PL in different countries are explained.
Angela Davey
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Publication Detail:
Type:  Historical Article; Journal Article     Date:  2006-05-06
Journal Detail:
Title:  Contraception     Volume:  74     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Exelgyn S.A, 216 Boulevard St. Germain, 75007 Paris.
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MeSH Terms
Abortifacient Agents, Steroidal / administration & dosage,  contraindications*
Abortion, Induced / contraindications*,  methods*
Cardiovascular Diseases / chemically induced
History, 20th Century
Legislation, Drug / history
Mifepristone / administration & dosage,  contraindications*
Prostaglandins / administration & dosage,  contraindications*
Risk Factors
Reg. No./Substance:
0/Abortifacient Agents, Steroidal; 0/Prostaglandins; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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