| Mifepristone combined with misoprostol versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy: a prospective, open-label, randomized clinical trial. | |
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MedLine Citation:
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PMID: 20434827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To compare the effectiveness and safety of mifepristone/misoprostol versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy. STUDY DESIGN: 210 women requesting voluntary termination of pregnancies at between 16 and 24 weeks of gestation were randomly assigned into two groups. Group 1 (MM) received a single oral dose of 200 mg mifepristone and, 36-48 h later, 400 microg of misoprostol vaginally, with up to three additional oral doses of 400 microg misoprostol every 12 h. Group 2 (EL) received an intra-amniotic injection of 100mg ethacridine lactate. The primary outcome was successful abortion rate. Secondary outcomes included the difference in the induction-to-abortion interval and the frequency of adverse events. RESULTS: Both MM and EL regimens were effective, with successful abortion rates of 96.19% and 94.29%, respectively (P=0.746). The complete abortion rates were 68.57% and 70.48%, respectively. The induction-to-abortion interval was longer in the MM group than in the EL group (50.57+/-6.80 h vs. 43.02+/-8.74 h, respectively, P<0.001). Both treatments were safe, although there was a significant difference in rates of gastrointestinal and fever adverse events between the two groups. CONCLUSIONS: Both MM and EL regimens were effective with high success rates and were safe for the termination of second trimester pregnancy. |
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Authors:
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Shuping Hou; Qinfang Chen; Lanrong Zhang; Aihua Fang; Linan Cheng |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 151 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 149-53 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage* Abortion, Induced / methods* Administration, Intravaginal Administration, Oral Adolescent Adult Chi-Square Distribution China Ethacridine / administration & dosage* Female Humans Middle Aged Mifepristone / administration & dosage* Misoprostol / administration & dosage* Pregnancy Pregnancy Trimester, Second Prospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 442-16-0/Ethacridine; 59122-46-2/Misoprostol; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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