Document Detail

Mifepristone (Ru486) antagonizes monocyte chemotactic protein-3 down-regulation at early mouse pregnancy revealing immunomodulatory events in Ru486 induced abortion.
MedLine Citation:
PMID:  15214937     Owner:  NLM     Status:  MEDLINE    
PROBLEM: The survival of an embryo bearing the paternal antigens within the immunocompetent environment of the maternal uterus renders 'pregnancy' to be a state of immunological paradox. The ratio of Th1/Th2 responses is crucial for pregnancy maintenance. Monocyte Chemotactic Protein-3 (MCP3) is a pro-inflammatory, CC chemokine and a Th1 effector which is capable of eliciting significant anti-tumoral immune responses. METHOD OF STUDY: MCP3 expression was investigated in the murine uterine tissue at different days of initial pregnancy and the effect of RU 486 in immature and delayed implantation model studied using Western blotting and Immunocytochemical techniques. RESULTS AND CONCLUSION: Our results show very high uterine MCP3 expression during pre-implantation followed by a significant MCP3 down-regulation at peri-implantation and low levels of MCP3 during post-implantation period. At the peri-implantation stage, embryos exhibited lowered MCP3 expression when compared with the pre-implantation stage. Ru486, a progesterone antagonist when given in a competitive mode with progesterone resulted in a massive surge in MCP3 expression in both immature mice and delayed implantation models. We hypothesize that it is imperative for MCP3 expression to be down-regulated for the success of pregnancy. The cross-talk between Ru486 and amplified MCP3 expression may be one of the mechanisms by way of which RU486 performs its abortificient and anti tumor role.
Jaya Nautiyal; Pradeep G Kumar; Malini Laloraya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  52     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-24     Completed Date:  2005-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  8-18     Citation Subset:  IM    
Embryo Implantation Group, Molecular Reproduction Unit, School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, Madhya Pradesh, India.
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MeSH Terms
Abortion, Induced*
Blastomeres / cytology,  drug effects,  metabolism
Chemokine CCL7
Cytokines / immunology*,  metabolism*
Down-Regulation / drug effects*
Embryo Implantation
Hormones / pharmacology
Mifepristone / pharmacology*
Models, Animal
Monocyte Chemoattractant Proteins / immunology*,  metabolism*
Pregnancy, Animal / immunology*,  physiology
Time Factors
Uterus / cytology,  drug effects,  immunology,  metabolism
Reg. No./Substance:
0/Ccl7 protein, mouse; 0/Chemokine CCL7; 0/Cytokines; 0/Hormones; 0/Monocyte Chemoattractant Proteins; 84371-65-3/Mifepristone

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