Document Detail

Midtrimester termination of complicated pregnancy with oral misoprostol.
MedLine Citation:
PMID:  9181185     Owner:  NLM     Status:  MEDLINE    
To define the mean effective dose of oral misoprostol, a PGE2 methylanalogue, for terminating midtrimester complicated pregnancy without producing significant side-effects and complications, forty-two patients with intrauterine complicated pregnancies of 14-28 weeks were treated with oral misoprostol. All patients were observed after the initial dose (200 micrograms). If there was no contraction of the uterus or no vaginal bleeding, a supplementary dose of 200 micrograms misoprostol was given once each hour, with an average total dose of 1000 micrograms being given (min. 200 micrograms, max. 1200 micrograms). Abortion was successfully induced in 39 women (92.9%); there were 3 failures (7.1%). The mean time from initial dose to abortion was 9 h. No important side-effects or complications were noted. This study demonstrated that the use of oral misoprostol is a simple, inexpensive and easy procedure for termination of second trimester complicated pregnancy.
S Batioğlu; E Tonguç; A Haberal; H Celikkanat; T Bağiş
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Advances in contraception : the official journal of the Society for the Advancement of Contraception     Volume:  13     ISSN:  0267-4874     ISO Abbreviation:  Adv Contracept     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-08-19     Completed Date:  1997-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607435     Medline TA:  Adv Contracept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Baskent University School of Medicine, Bahcelievler, Ankara, Turkey.
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MeSH Terms
Abortifacient Agents, Nonsteroidal*
Abortion, Induced / methods*
Pregnancy Complications*
Pregnancy Trimester, Second
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

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