| Midtrimester amniotic fluid tumor necrosis factor-alpha does not predict small-for-gestational-age infants. | |
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MedLine Citation:
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PMID: 9127645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: To evaluate the independent ability of midtrimester amniotic fluid tumor necrosis factor-alpha (TNF-alpha) in the prediction of small-for-gestational-age (SGA) infants. METHOD OF STUDY: In this case-control study, patients delivering a SGA infant were matched with controls based on GA at delivery, maternal age, race, and parity. Patients with immune disease, chronic hypertension, diabetes, asthma, congenital hearts disease, multiple gestation, and fetal anomalies were excluded. Amniotic fluid samples were immunoassayed for TNF-alpha. Potential confounding variables evaluated were maternal serum alpha-fetoprotein level, smoking history, pregnancy induced hypertension, and neonatal gender. Statistical analysis included Fisher's exact test and ANOVA after log transformation with P < 0.05 considered significant. RESULTS: Eighteen patients delivered SGA neonates and were matched with 41 controls. No significant differences were identified in the confounding variables between patients with SGA neonates and controls. Amniotic fluid TNF-alpha levels were not significantly different between patients subsequently delivering SGA neonates and controls [median 7.63 (range 0.25-16.1) pg/mL versus 9.39 (0.25-66.9) pg/mL, P = 0.8]. CONCLUSIONS: Midtrimester amniotic fluid TNF-alpha levels are not predictive of SGA neonates when compared with controls matched for gestational age at delivery. |
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Authors:
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C Y Spong; D M Scherer; A Ghidini; J C Pezzullo; C M Salafia; G S Eglinton |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 37 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-06-24 Completed Date: 1997-06-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 236-9 Citation Subset: IM |
Affiliation:
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Perinatal Research Branch, NICHD, Washington DC, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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chemistry,
immunology* Biological Markers / analysis Case-Control Studies Female Humans Infant, Newborn Infant, Small for Gestational Age / immunology* Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Risk Factors Tumor Necrosis Factor-alpha / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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N01-HD-3-3198/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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