Document Detail

Midtrimester abortion using vaginal misoprostol for women with three or more prior cesarean deliveries.
MedLine Citation:
PMID:  20362989     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the safety and efficacy of vaginal misoprostol for second-trimester abortion in women with 3 or more prior cesarean deliveries. METHODS: This study was conducted with 138 women who needed pregnancy termination between 13 and 26 gestational weeks, 31 with 3 or more previous cesarean deliveries and 107 with no uterine scars (the controls). Misoprostol was inserted in the vagina every 6 hours until regular contractions or products of conception appeared, a 200-microg tablet for the first 24 hours and 2 tablets thereafter. The outcomes assessed were successful vaginal abortion, hemorrhage requiring blood transfusion, incomplete abortion, and uterine rupture. RESULTS: A vaginal abortion occurred in 28 women (90.3%) in the study group and 107 (100%) in the control group (P=0.01). There were no significant differences in the prevalence of the other assessed outcomes. CONCLUSION: Vaginal misoprostol appears to be safe and acceptably effective for second-trimester pregnancy termination in women with 3 or more previous cesarean deliveries.
Muhammad Fawzy; El-Said Abdel-Hady
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Publication Detail:
Type:  Journal Article     Date:  2010-04-02
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  110     ISSN:  1879-3479     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  50-2     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage,  adverse effects,  therapeutic use*
Abortion, Induced / methods*
Administration, Intravaginal
Case-Control Studies
Cesarean Section / adverse effects
Cicatrix / complications*,  etiology
Misoprostol / administration & dosage,  adverse effects,  therapeutic use*
Pregnancy Trimester, Second
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

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