| Midtrimester abortion induced by serial intramuscular injections of 15(S)-15-methyl-prostaglandin E2 methyl ester. | |
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MedLine Citation:
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PMID: 1200057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Midtrimester abortion was successfully induced in 29 of 30 patients with serial intramuscular injections of 15(S)-15-methyl-prostaglandin E2 methyl ester (15-ME-PGE2). The mean abortion time was 9.52 hours; parous patients aborted somewhat faster (mean, 8.76 hours) than nulliparous patients (mean, 10.47 hours). Eight patients were monitored throughout the abortion procedure and uterine activity was calculated and analyzed. Uterine response to a single injection of 5 mug 15-ME-PGE2 was characterized by the rapid appearance of low-amplitude, high-frequency contractions accompanied by a rise in intrauterine baseline tonus. Uterine activity rose to a mean of 500 Montevideo Units within 40 minutes of the initial intramuscular injection of 15-ME-PGE2. The most frequently encountered side effect of intramuscular injections of 15-ME-PGE2 was temperature elevation of 2 degrees F. or higher, which occurred in 29 of 30 patients. Five patients complained of shaking and chills but only five patients had any gastrointestinal side effects. From this study it appeared that on a weight-for-weight basis 15-ME-PGE2 is at least 20 times more potent than 15-ME-PGE2alpha and 1,000 time more potent than the naturally occurring PGE2. |
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Authors:
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N H Lauersen; N J Secher; K H Wilson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 123 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1975 Dec |
Date Detail:
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Created Date: 1976-02-09 Completed Date: 1976-02-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 665-70 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents
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administration & dosage* Abortion, Induced* Adolescent Adult Female Fever / chemically induced Humans Injections, Intramuscular Parity Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Prostaglandins E / administration & dosage*, adverse effects, pharmacology, therapeutic use Uterine Contraction / drug effects Vomiting / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents; 0/Prostaglandins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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