Document Detail

Midterm outcome of ultrasound-guided alcohol gel sclerotherapy for symptomatic leiomyoma.
MedLine Citation:
PMID:  20733188     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to describe the outcome of ultrasound-guided ethanol gel sclerotherapy of myomatous nodules 1 to 18 months after treatment.
METHODS: A total of 118 consecutive patients with a diagnosis of symptomatic leiomyomas referred for ethanol gel sclerotherapy were studied between November 2005 and July 2007. Clinical (self-administered symptom questionnaire) and ultrasound follow-ups were done 1 to 2, 6 to 8, and 12 to 18 months after the procedure.
RESULTS: The mean baseline volumes +/- SD were 223.3 +/- 158.3 cm(3) for the uterus and 68.4 +/- 110.5 cm(3) for the dominant fibroid. The most common adverse reaction in the immediate postoperative period was pelvic pain in 27.1% of the patients, but 58.4% had no reactions. After 12 months, a 29.5% reduction in uterine volume was observed in 64.7% of the patients. A 55.5% reduction in dominant fibroid volume was observed in 82.8% of the patients. Pelvic pain improved in 29.8% of the sample, dysmenorrhea in 51.7%, and menstrual flow in 39%. Most patients (77%) reported being satisfied or very satisfied with the treatment.
CONCLUSIONS: The results suggest that ethanol gel sclerotherapy is a safe, conservative alternative for treating symptomatic uterine leiomyomas. Further randomized studies are necessary to determine the suitability and indications of this procedure in comparison to other minimally invasive techniques.
Lucilo Avila Pessoa; Fernando Gurgel; Mirela Avila; Maria da Conceição Souto Maior; Valeria Maria Bezerra Silva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  29     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1323-30     Citation Subset:  IM    
Department of Ultrasonography, Centro Diagnóstico Lucilo Avila Júnior, Recife, Brazil.
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MeSH Terms
Chi-Square Distribution
Ethanol / administration & dosage
Leiomyoma / therapy*,  ultrasonography
Middle Aged
Sclerotherapy / methods*
Treatment Outcome
Ultrasonography, Interventional*
Uterine Neoplasms / therapy*,  ultrasonography
Reg. No./Substance:
0/Gels; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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