Document Detail


Midterm outcome of ultrasound-guided alcohol gel sclerotherapy for symptomatic leiomyoma.
MedLine Citation:
PMID:  20733188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to describe the outcome of ultrasound-guided ethanol gel sclerotherapy of myomatous nodules 1 to 18 months after treatment.
METHODS: A total of 118 consecutive patients with a diagnosis of symptomatic leiomyomas referred for ethanol gel sclerotherapy were studied between November 2005 and July 2007. Clinical (self-administered symptom questionnaire) and ultrasound follow-ups were done 1 to 2, 6 to 8, and 12 to 18 months after the procedure.
RESULTS: The mean baseline volumes +/- SD were 223.3 +/- 158.3 cm(3) for the uterus and 68.4 +/- 110.5 cm(3) for the dominant fibroid. The most common adverse reaction in the immediate postoperative period was pelvic pain in 27.1% of the patients, but 58.4% had no reactions. After 12 months, a 29.5% reduction in uterine volume was observed in 64.7% of the patients. A 55.5% reduction in dominant fibroid volume was observed in 82.8% of the patients. Pelvic pain improved in 29.8% of the sample, dysmenorrhea in 51.7%, and menstrual flow in 39%. Most patients (77%) reported being satisfied or very satisfied with the treatment.
CONCLUSIONS: The results suggest that ethanol gel sclerotherapy is a safe, conservative alternative for treating symptomatic uterine leiomyomas. Further randomized studies are necessary to determine the suitability and indications of this procedure in comparison to other minimally invasive techniques.
Authors:
Lucilo Avila Pessoa; Fernando Gurgel; Mirela Avila; Maria da Conceição Souto Maior; Valeria Maria Bezerra Silva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  29     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1323-30     Citation Subset:  IM    
Affiliation:
Department of Ultrasonography, Centro Diagnóstico Lucilo Avila Júnior, Recife, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chi-Square Distribution
Ethanol / administration & dosage
Female
Gels
Humans
Leiomyoma / therapy*,  ultrasonography
Middle Aged
Questionnaires
Sclerotherapy / methods*
Treatment Outcome
Ultrasonography, Interventional*
Uterine Neoplasms / therapy*,  ultrasonography
Chemical
Reg. No./Substance:
0/Gels; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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