| Midterm results of uterine artery embolization using narrow-size calibrated embozene microspheres. | |
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MedLine Citation:
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PMID: 20953610 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To evaluate safety and efficacy of uterine artery embolization using narrow-size-range polyphosphazene-coated hydrogel microspheres (Embozene, CeloNova Biosciences, Newnan, GA). METHODS: Between May 2006 and September 2008, a total of 121 consecutive patients (mean ± SD age 42.1 ± 5.4 years, range 30.5-51.5 years) were enrolled onto this single-center study. The primary study endpoint was safety as assessed by the society of interventional radiology (SIR) classification. The secondary endpoint was efficacy, which was based on a 1-year magnetic resonance imaging study and relief of symptoms documented by the Medical Outcomes Study 36-Item Short-Form Health Survey questionnaire over a 2-year interval. RESULTS: The mean ± SD diameter of the dominant fibroid was 6.4 ± 2.6 (range, 2.9-13.9) cm and the mean volume 137.2 ± 245.1 (range, 5.3-1184) ml. Most patients had multiple fibroids with 11% more than 10. A total of 240 of 242 interventions were completed as planned, a technical success rate of 99.2%. According to the SIR classification, one type A, eight type C, and one type D complication occurred. Total devascularization was noted in 96% (116 of 121) of dominant fibroids. Volume decrease was 4% at 2 weeks, 52% (P < 0.001) at 3 months, 78% (P < 0.001) at 6 months, and 91% at 12 months (P < 0.001). The latter difference was statistically significant (P = 0.007). A total of 92% had improved hypermenorrhea at 1 year and 94% at 2 years. Dysmenorrhea was improved in 96% at 1 year and in 95% at 2 years. The overall health status score was 60.4 ± 26.2 points at baseline and 96.9 ± 3.8 after 1 year (P = 0.0019). CONCLUSION: Uterine artery embolization with Embozene microspheres is a safe procedure. Its efficacy is demonstrated by high fibroid devascularization and volume reduction rates and significant improvements of clinical symptoms and quality-of-life scores during follow-up. |
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Authors:
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Ulrike Stampfl; Boris Radeleff; Christof Sommer; Sibylle Stampfl; Angelika Dahlke; Nadine Bellemann; Hans-Ulrich Kauczor; Goetz M Richter |
Publication Detail:
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Type: Journal Article Date: 2010-10-15 |
Journal Detail:
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Title: Cardiovascular and interventional radiology Volume: 34 ISSN: 1432-086X ISO Abbreviation: Cardiovasc Intervent Radiol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003538 Medline TA: Cardiovasc Intervent Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 295-305 Citation Subset: IM |
Affiliation:
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Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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