| Midterm Outcomes and Quality of Life of Aortic Root Replacement: Mechanical vs Biological Conduits. | |
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MedLine Citation:
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PMID: 21459276 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Aortic root replacement is a complex operation for severe aortic root pathology such as aneurysms and dissections with concomitant aortic valve disease. Biological and mechanical valve conduits are available. METHODS: Early and midterm results were analyzed in patients undergoing aortic root replacement. From January 1, 1998, to May 31, 2007, 144 patients underwent aortic root replacement (Bentall procedures) with either a mechanical (n = 51) or a biological (n = 93) valve conduit. Cox proportional hazard analysis was used to determine whether valve type was an independent predictor of all-cause mortality, and analysis of covariance was used to compare general and disease-specific health-related quality-of-life scores. RESULTS: Operative mortality was 2.1%. Median follow-up time was 40 months; 1- and 5-year survival rates for the mechanical group were 96.0% and 89.0%, respectively, vs 93.0% and 84.0% for the biological group. Valve type was not predictive of all-cause mortality, and valve-related complications were not significantly different between groups. At follow-up, 31.5% of patients in the biological group were on anticoagulant. General and disease-specific health-related quality-of-life scores were not significantly different between groups. CONCLUSIONS: Aortic root replacement with either mechanical or biological valved conduits is a safe procedure. Morbidity, mortality, and adverse quality of life were not associated with the type of valve conduit. Further studies are required to assess long-term durability of biological valve conduits used for aortic root replacement. |
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Authors:
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Eric J Lehr; Peter Z T Wang; Antigone Oreopoulos; Hussein Kanji; Colleen Norris; Roderick Macarthur |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 27 ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 262.e15-20 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Division of Cardiac Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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