Document Detail


Midpregnancy levels of angiogenic markers in relation to maternal characteristics.
MedLine Citation:
PMID:  21145529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to describe relations among maternal demographic and lifestyle characteristics and midpregnancy levels of angiogenic markers (soluble Fms-like tyrosine kinase-1, placental growth factor, soluble endoglin).
STUDY DESIGN: In a large pregnancy cohort, linear models were used to evaluate relations among maternal characteristics and midpregnancy angiogenic markers with and without covariate adjustment. Associations were examined in a subcohort that included term and preterm deliveries (n = 1302) and among "normal" term pregnancies (n = 668).
RESULTS: Concentrations of all factors declined with increasing maternal body mass index. Multiparous women had lower soluble Fms-like tyrosine kinase-1 levels than primiparous women. Higher placental growth factor and slightly lower soluble endoglin levels were observed among women who smoked at enrollment, but not among those women who quit before enrollment. African American women had higher levels of all markers.
CONCLUSION: Understanding relations among maternal characteristics and levels of angiogenic factors may improve studies that use these markers to examine etiology and/or to predict adverse pregnancy outcome.
Authors:
Renée S Mijal; Claudia B Holzman; Sarosh Rana; S Ananth Karumanchi; Jianling Wang; Alla Sikorskii
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2010-12-10
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-06-29     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244.e1-12     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Department of Epidemiology, Michigan State University, East Lansing, MI, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiogenesis Inducing Agents / blood
Anthropometry
Antigens, CD / blood*
Biological Markers / blood
Female
Humans
Life Style*
Pregnancy
Pregnancy Outcome
Pregnancy Proteins / blood*
Pregnancy Trimester, Second / blood*
Receptors, Cell Surface / blood*
Smoking*
Socioeconomic Factors
Vascular Endothelial Growth Factor Receptor-1 / blood*
Young Adult
Grant Support
ID/Acronym/Agency:
5K12HD001255/HD/NICHD NIH HHS; R01 HD034543-03/HD/NICHD NIH HHS; R01 HD034543-04/HD/NICHD NIH HHS; R01 HD034543-05A1/HD/NICHD NIH HHS; R01 HD034543-06/HD/NICHD NIH HHS; R01 HD034543-07/HD/NICHD NIH HHS; R01 HD034543-07S1/HD/NICHD NIH HHS; R01 HD034543-08/HD/NICHD NIH HHS; R01 HD34543/HD/NICHD NIH HHS; T32 HD046377/HD/NICHD NIH HHS; U01 DP000143-01/DP/NCCDPHP CDC HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Antigens, CD; 0/Biological Markers; 0/ENG protein, human; 0/Pregnancy Proteins; 0/Receptors, Cell Surface; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1
Comments/Corrections
Erratum In:
Am J Obstet Gynecol. 2011 Jul;205(1):84

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