Document Detail

Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension.
MedLine Citation:
PMID:  15198285     Owner:  NLM     Status:  MEDLINE    
Many astronauts exhibit post-spaceflight orthostatic hypotension due to inadequate norepinephrine release when in an upright posture. We hypothesized that an alpha1-adrenergic agonist, midodrine, would be an effective countermeasure. A female astronaut, who had problems with postflight orthostatic hypotension after a previous flight, consumed 10 mg midodrine after a subsequent flight, prior to her tilt test. Hemodynamic variables were compared between the two flights. Midodrine prevented severe falls in stroke volume, cardiac output and systolic pressure, and severe increases in heart rate without increasing vascular resistance, thus preventing orthostatic hypotension. This is the first report showing that midodrine has the potential to improve post-spaceflight orthostatic hypotension and suggesting that reduced venous return contributes to the etiology.
Steven H Platts; Michael G Ziegler; Wendy W Waters; Brett M Mitchell; Janice V Meck
Related Documents :
9796135 - Syncope in a 65-year-old woman after nitrate ingestion.
1592445 - Orthostatic hypotension in older adults. the cardiovascular health study. chs collabora...
6875105 - Abnormal neurohumoral response to nitroprusside infusion in congestive heart failure.
14692465 - Baroreflex control of heart rate during heating in subjects with low orthostatic tolera...
24747555 - Combined impact of lead, cadmium, polychlorinated biphenyls and non-chemical risk facto...
16552245 - Measuring intraocular pressure-adjustments for corneal thickness and new technologies.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  75     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-16     Completed Date:  2004-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  554-6     Citation Subset:  IM; S    
Universities Space Research Association, Houston, TX, USA.
Space Flight Mission:
Flight Experiment; STS Shuttle Project; manned; short duration
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic alpha-Agonists / pharmacology,  therapeutic use*
Cardiac Output / drug effects
Heart Rate
Hypotension, Orthostatic / drug therapy*
Midodrine / pharmacology,  therapeutic use*
Space Flight*
Stroke Volume / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 42794-76-3/Midodrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Measurement of force exerted on footplates by centrifuge subjects.
Next Document:  Anatomical studies of the female genitalia: surgical reconstructive implications.