Document Detail


Midodrine prescribed to improve recurrent post-spaceflight orthostatic hypotension.
MedLine Citation:
PMID:  15198285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many astronauts exhibit post-spaceflight orthostatic hypotension due to inadequate norepinephrine release when in an upright posture. We hypothesized that an alpha1-adrenergic agonist, midodrine, would be an effective countermeasure. A female astronaut, who had problems with postflight orthostatic hypotension after a previous flight, consumed 10 mg midodrine after a subsequent flight, prior to her tilt test. Hemodynamic variables were compared between the two flights. Midodrine prevented severe falls in stroke volume, cardiac output and systolic pressure, and severe increases in heart rate without increasing vascular resistance, thus preventing orthostatic hypotension. This is the first report showing that midodrine has the potential to improve post-spaceflight orthostatic hypotension and suggesting that reduced venous return contributes to the etiology.
Authors:
Steven H Platts; Michael G Ziegler; Wendy W Waters; Brett M Mitchell; Janice V Meck
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  75     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-16     Completed Date:  2004-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  554-6     Citation Subset:  IM; S    
Affiliation:
Universities Space Research Association, Houston, TX, USA.
Space Flight Mission:
Flight Experiment; STS Shuttle Project; manned; short duration
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology,  therapeutic use*
Cardiac Output / drug effects
Female
Heart Rate
Humans
Hypotension, Orthostatic / drug therapy*
Midodrine / pharmacology,  therapeutic use*
Recurrence
Space Flight*
Stroke Volume / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 42794-76-3/Midodrine
Investigator
Investigator/Affiliation:
J V Meck / NASA JSC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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