Document Detail

Midlife healthy-diet index and late-life dementia and Alzheimer's disease.
MedLine Citation:
PMID:  22163237     Owner:  NLM     Status:  PubMed-not-MEDLINE    
AIM: To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD).
METHODS: Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components.
RESULTS: Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders.
CONCLUSIONS: Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible.
Marjo H Eskelinen; Tiia Ngandu; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto
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Publication Detail:
Type:  Journal Article     Date:  2011-04-27
Journal Detail:
Title:  Dementia and geriatric cognitive disorders extra     Volume:  1     ISSN:  1664-5464     ISO Abbreviation:  Dement Geriatr Cogn Dis Extra     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101564825     Medline TA:  Dement Geriatr Cogn Dis Extra     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  103-12     Citation Subset:  -    
Department of Neurology, University of Eastern Finland, Kuopio, Kuopio, Finland.
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