Document Detail


Midlife healthy-diet index and late-life dementia and Alzheimer's disease.
MedLine Citation:
PMID:  22163237     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
AIM: To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD).
METHODS: Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components.
RESULTS: Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders.
CONCLUSIONS: Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible.
Authors:
Marjo H Eskelinen; Tiia Ngandu; Jaakko Tuomilehto; Hilkka Soininen; Miia Kivipelto
Related Documents :
21677127 - Associations between dietary patterns and ldl peak particle diameter: a cross-sectional...
17981877 - Floral development in the tribe cedreleae (meliaceae, sub-family swietenioideae): cedre...
21640757 - Vitamin d and metabolic health with special reference to the effect of vitamin d on ser...
22019947 - Association of subcutaneous and visceral fat mass with serum concentrations of adipokin...
8656067 - Identification and cholesterol quantification of low density lipoprotein subclasses in ...
1161707 - Effects of short term phosphorus deprivation on laying hens.
Publication Detail:
Type:  Journal Article     Date:  2011-04-27
Journal Detail:
Title:  Dementia and geriatric cognitive disorders extra     Volume:  1     ISSN:  1664-5464     ISO Abbreviation:  Dement Geriatr Cogn Dis Extra     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101564825     Medline TA:  Dement Geriatr Cogn Dis Extra     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  103-12     Citation Subset:  -    
Affiliation:
Department of Neurology, University of Eastern Finland, Kuopio, Kuopio, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Proactive approach in detecting elderly subjects with cognitive decline in general practitioners' pr...
Next Document:  Amnestic mild cognitive impairment and early Alzheimer's disease in an asian memory clinic - evidenc...