Document Detail

Midlife gene expressions identify modulators of aging through dietary interventions.
MedLine Citation:
PMID:  22509016     Owner:  NLM     Status:  MEDLINE    
Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. We found that pathways transcriptionally correlated with diet-modulated lifespan and physiological changes were enriched for lifespan-modifying genes. Intriguingly, mitochondrial gene expression correlated with lifespan and anticorrelated with aging-related pathological changes, whereas peroxisomal gene expression showed an opposite trend. Both organelles produce reactive oxygen species, a proposed causative factor of aging. This finding implicates a contribution of peroxisome to aging. Consistent with this hypothesis, lowering the expression levels of peroxisome proliferation genes decreased the cellular peroxide levels and extended the lifespan of Drosophila melanogaster and Caenorhabditis elegans. These findings show that transcriptional changes resulting from dietary interventions can effectively reflect causal factors in aging and identify previously unknown or under-appreciated longevity pathways, such as the peroxisome pathway.
Bing Zhou; Liu Yang; Shoufeng Li; Jialiang Huang; Haiyang Chen; Lei Hou; Jinbo Wang; Christopher D Green; Zhen Yan; Xun Huang; Matt Kaeberlein; Li Zhu; Huasheng Xiao; Yong Liu; Jing-Dong J Han
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-16
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-09     Completed Date:  2012-08-13     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1201-9     Citation Subset:  IM    
Chinese Academy of Sciences Key Laboratory for Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Data Bank Information
Bank Name/Acc. No.:
GEO/GSE36836;  GSE36838
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MeSH Terms
Aging / genetics*,  metabolism,  physiology
Caenorhabditis elegans / genetics,  metabolism,  physiology
Cluster Analysis
Drosophila melanogaster / genetics,  metabolism,  physiology
Energy Metabolism
Gene Expression Profiling*
Hydrogen Peroxide / metabolism
Longevity / genetics*,  physiology
Mice, Inbred C57BL
Microscopy, Electron, Transmission
Mitochondria, Liver / genetics,  metabolism,  ultrastructure
Oligonucleotide Array Sequence Analysis
Peroxisomes / genetics,  metabolism
RNA Interference
Reactive Oxygen Species / metabolism
Grant Support
Reg. No./Substance:
0/Reactive Oxygen Species; 7722-84-1/Hydrogen Peroxide

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