| Middle temporal visual area microstimulation influences veridical judgments of motion direction. | |
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MedLine Citation:
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PMID: 12417677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microstimulation of direction columns in the middle temporal visual area (MT, or V5) provides a powerful tool for probing the relationship between cortical physiology and visual motion perception. In the current study we obtained "veridical" reports of perceived motion from rhesus monkeys by permitting a continuous range of possible responses that mapped isomorphically onto a continuous range of possible motion directions. In contrast to previous studies, therefore, the animals were freed from experimenter-imposed "categories" that typify forced choice tasks. We report three new findings: (1) MT neurons with widely disparate preferred directions can cooperate to shape direction estimates, inconsistent with a pure "winner-take-all" read-out algorithm and consistent with a distributed coding scheme like vector averaging, whereas neurons with nearly opposite preferred directions seem to compete in a manner consistent with the winner-take-all hypothesis, (2) microstimulation can influence direction estimates even when paired with the most powerful motion stimuli available, and (3) microstimulation effects can be elicited when a manual response (instead of our standard oculomotor response) is used to communicate the perceptual report. |
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Authors:
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M James Nichols; William T Newsome |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 22 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-05 Completed Date: 2002-11-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 9530-40 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Brain Mapping Electric Stimulation / methods Fixation, Ocular / physiology Judgment / physiology* Macaca mulatta Microelectrodes Models, Neurological Motion Perception / physiology* Neurons / physiology Photic Stimulation / methods Reproducibility of Results Saccades / physiology Temporal Lobe / physiology* Visual Cortex / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY05603/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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