| Middle cerebral artery-peak systolic velocity in dizygotic twins with anti-E alloimmunization. | |
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MedLine Citation:
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PMID: 21040209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Middle cerebral artery-peak systolic velocity (MCA-PSV) has been reported to predict fetal anemia with similar accuracy as amniotic ΔOD450 assay. Alloimmunized dizygotic twin pregnancy allows us to compare anemic and non-anemic twins in the same intrauterine environment. We herein present a case of Rh (E)-incompatible dizygotic twin pregnancy, where MCA-PSV could precisely detect the anemia in one of the twins. A 36-year-old woman, whose previous child required exchange transfusion due to hemolytic anemia of newborn (HFDN), conceived twins after in vitro fertilization-embryo transfer. At 24 weeks' gestation, MCA-PSV of twin A and twin B were 23.9 cm/s (0.8 multiples of median; MoM) and 30.7 cm/s (1.0 MoM), respectively. At 31 weeks' gestation, MCA-PSV values of both twins were sharply elevated to nearly 1.4 MoM. Thereafter, MCA-PSV of twin A fell to 1.0 MoM, whereas MCA-PSV of twin B exceeded 1.5 MoM at 34 weeks' gestation. Development of fetal anemia was suspected and emergency cesarean section was performed. Twin B showed moderate anemia with positive direct Coombs' test and was diagnosed as HFDN due to anti-E alloimmunization. Twin B required phototherapy and red cell transfusion, but exchange transfusion was safely obviated. |
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Authors:
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Yumiko Satake; Yukiyasu Sato; Noriomi Matsumura; Keiji Tatsumi; Hiroshi Fujiwara; Ikuo Konishi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-10-11 |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 36 ISSN: 1447-0756 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-30 Completed Date: 2011-03-30 Revised Date: 2012-01-19 |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: Australia |
Other Details:
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Languages: eng Pagination: 1236-9 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology. |
Affiliation:
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Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Neonatal / immunology, physiopathology, ultrasonography* Blood Flow Velocity Blood Group Incompatibility / complications*, physiopathology Female Fetal Diseases / etiology, physiopathology, ultrasonography* Humans Infant, Newborn Middle Cerebral Artery / ultrasonography* Pregnancy Twins, Dizygotic / physiology* Ultrasonography, Prenatal |
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