Document Detail

Middle cerebral artery occlusion in the young rat.
MedLine Citation:
PMID:  7147305     Owner:  NLM     Status:  MEDLINE    
This investigation describes a surgical approach for ligation of the middle cerebral artery (MCA) in the young rat and evaluates consequences of the occlusion with a neurologic exam for motor deficits, Evans blue test for blood-brain barrier leaks, and light microscopy for histologic changes after 3 days. Evans blue extravasation and the lesion were limited to cortex at the burr hole site in occluded and sham operated rats. MCA occlusion beyond the point of origin of the striate branches in the young rat results in neither neurological deficits, dye markings, nor histologic changes in the distal vascular field to indicate an infarct. Apparently, the young rodent collateral supply maintains the tissue in a viable state.
P Coyle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  13     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  855-9     Citation Subset:  IM    
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MeSH Terms
Arterial Occlusive Diseases / physiopathology*
Blood-Brain Barrier
Cerebral Arteries* / surgery
Cerebral Cortex / pathology
Cerebral Infarction / pathology,  physiopathology*
Cerebrovascular Circulation*
Collateral Circulation
Evans Blue / diagnostic use
Ligation / methods
Rats, Inbred Strains
Grant Support
18575//PHS HHS
Reg. No./Substance:
314-13-6/Evans Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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