| Middle cerebral artery occlusion in the rabbit using selective angiography: application for assessment of thrombolysis. | |
| | |
MedLine Citation:
|
PMID: 18340097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: An animal model of selective middle cerebral artery (MCA) occlusion is needed for evaluation of intra-arterial (IA) delivery of thrombolytic agents. We describe a technique for MCA thrombo-occlusion in the rabbit with real-time angiographic documentation of occlusion and thrombolytic recanalization. METHODS: After femoral artery cutdown, a microcatheter was advanced from the internal carotid artery to the MCA. MCA occlusion was achieved by IA thrombin and reperfusion by IA plasmin. RESULTS: The terminal internal carotid artery was successfully catheterized in 12 of 13 animals. Stable (2-hour) MCA occlusion was induced and verified angiographically in all 12 animals; 2 animals also had distal internal carotid artery thrombus. Recanalization was achieved rapidly after IA plasmin in 3 of 3 animals. CONCLUSIONS: We describe a new animal model of selective MCA occlusion documented by real-time angiography and used to demonstrate recanalization with IA plasmin. |
| | |
Authors:
|
Reza Jahan; Daphne Stewart; Harry V Vinters; William Yong; Fernando Vinuela; Pete Vandeberg; Victor J Marder |
Related Documents
:
|
22008977 - Heparin-induced thrombocytopenia in the presence of a heparin-bonded bypass graft. 9694087 - Correction of congenital diaphragmatic hernia in utero ix: fetuses with poor prognosis ... 17192527 - Discriminating between right coronary artery and circumflex artery occlusion by using a... 11385157 - "wireless" laser recanalization of chronic total coronary occlusions. 17349347 - The mid-distal deep femoral artery: few important centimeters in vascular surgery. 2869697 - Automaticity in atrioventricular valve leaflets of rabbit heart. |
Publication Detail:
|
Type: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-03-13 |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 39 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-04-29 Completed Date: 2008-05-29 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
|
Languages: eng Pagination: 1613-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cerebral Angiography / methods* Disease Models, Animal Fibrinolysin / pharmacology, therapeutic use Fibrinolytic Agents / pharmacology, therapeutic use Infarction, Middle Cerebral Artery / chemically induced, drug therapy*, pathology* Intracranial Embolism / chemically induced, drug therapy*, pathology* Middle Cerebral Artery / drug effects, pathology, radiography Predictive Value of Tests Rabbits Thrombin Thrombolytic Therapy / methods* Treatment Outcome Vascular Surgical Procedures |
| Grant Support | |
ID/Acronym/Agency:
|
P50 NS 44378/NS/NINDS NIH HHS; P50 NS044378-05/NS/NINDS NIH HHS; R0 1 HL 07451/HL/NHLBI NIH HHS; R01 HL074051-04/HL/NHLBI NIH HHS; T32 HL 66992/HL/NHLBI NIH HHS; T32 HL066992-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fibrinolytic Agents; EC 3.4.21.5/Thrombin; EC 3.4.21.7/Fibrinolysin |
| Comments/Corrections | |
Comment In:
|
Stroke. 2008 Nov;39(11):e165; author reply e166
[PMID:
18832740
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Observation of the lenticulostriate arteries in the human brain in vivo using 7.0T MR angiography.
Next Document: Sonothrombolysis with transcranial color-coded sonography and recombinant tissue-type plasminogen ac...