Document Detail

Middle cerebral arterial thrombosis in a patient with hypofibrinogenemia, 5 days after rFVIIa and FFP infusion.
MedLine Citation:
PMID:  16444445     Owner:  NLM     Status:  MEDLINE    
A 13-year-old female patient is presented who had hypofibrinogenemia diagnosed as von Willebrand disease at 5 years of age at another hospital. She was admitted to the department of pediatric hematology with a severe headache, vomiting, and progressive right flaccid hemiplegia and lethargy. Contrast-enhanced computed tomography scan showed subdural hematoma in posterior parietal region of the brain and impending cerebellar herniation. She was given fresh-frozen plasma (FFP) and then activated factor VII (rFVIIa), 80 microg/kg was infused for replacement of von Willebrand factor. The subdural hematoma was emergently drained. The results of coagulation tests before infusion of FFP and rFVIIa revealed hypofibrinogenemia, and FFP was given every 48 hours. The patient recovered dramatically in a few days. Five days after rFVIIa infusion, a magnetic resonance angiography-proven right middle cerebral arterial thrombosis developed. It is an interesting point of discussion whether the middle cerebral arterial thrombosis was provoked as a consequence of rFVIIa and FFP infusion.
Turkan Patiroglu; Musa Karakukcu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  12     ISSN:  1076-0296     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-05-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-3     Citation Subset:  IM    
Erciyes University Medical School, Department of Pediatric Hematology, Kayseri-Turkey.
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MeSH Terms
Afibrinogenemia / complications*,  drug therapy
Blood Component Transfusion / adverse effects*
Factor VII / adverse effects*,  therapeutic use
Factor VIIa
Hematoma, Subdural / chemically induced,  etiology
Infarction, Middle Cerebral Artery / chemically induced*,  etiology
Magnetic Resonance Angiography
Recombinant Proteins / adverse effects,  therapeutic use
von Willebrand Diseases / complications,  drug therapy
Reg. No./Substance:
0/Recombinant Proteins; 0/recombinant FVIIa; 9001-25-6/Factor VII; EC VIIa
Comment In:
Clin Appl Thromb Hemost. 2009 Feb;15(1):125   [PMID:  19150998 ]

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