| Middle Cerebellar Peduncles and Pontine T2 Hypointensities in ARSACS. | |
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MedLine Citation:
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PMID: 22268491 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Magnetic resonance imaging (MRI) of autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) cases in Quebec and Europe was reported to show linear hypointensities in T2-weighted and Fluid Attenuated Inversion Recovery (FLAIR) images of the pons. We attempted to clarify the characteristics of the brain MRI findings in ARSACS cases. METHODS: Eight Japanese early-onset ataxia patients with ARSACS confirmed molecularly were investigated. We performed neurological examination, SACS gene analysis, and MRI in the patients. RESULTS: Hypointensity lesions in the middle cerebellar peduncles in addition to the pons were observed in T2-weighted and FLAIR images in all eight cases. Although superior cerebellar atrophy was seen in all cases, this MRI finding might not be specific for ARSACS. Upper cervical cord and medulla oblongata atrophy was not observed in 3 of the 7 patients examined. CONCLUSION: Not only pontine but also middle cerebellar peduncle hypointensity lesions observed in T2-weighted and FLAIR images could be specific findings for ARSACS even in cases with variable clinical phenotypes. J Neuroimaging 2012;XX:1-4. |
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Authors:
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Haruo Shimazaki; Yoshihisa Takiyama; Junko Honda; Kumi Sakoe; Michito Namekawa; Jun Tsugawa; Yoshio Tsuboi; Chieko Suzuki; Masayuki Baba; Imaharu Nakano |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: - ISSN: 1552-6569 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 by the American Society of Neuroimaging. |
Affiliation:
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From the Division of Neurology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan (HS, JH, KS, MN, IN); Department of Neurology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan (YT); Department of Neurology, Fukuoka University, Fukuoka, Japan (JT, YT); and Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan (CS, MB). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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