| Midbrain stimulation inhibits tail-flick only at currents sufficient to excite rostral medullary neurons. | |
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MedLine Citation:
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PMID: 6498508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of midbrain electrical stimulation on the activity of tail-flick (TF) related neurons in the rostral ventromedial medulla (RVM) were studied. Neurons whose activity either decreased (off-cells) or increased (on-cells) immediately prior to TF were examined. Of 31 off- and on-cells, 26 (84%) showed increased activity during midbrain stimulation sufficient to suppress the TF. Furthermore, in 21 of these cells, the threshold for activation was identical to the threshold for TF suppression, and in the other 5 cells the threshold difference was less than or equal to 5 microA. This study provides evidence that off-and on-cells in the RVM mediate the antinociceptive actions of midbrain stimulation. |
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Authors:
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H Vanegas; N M Barbaro; H L Fields |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 321 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1985-01-23 Completed Date: 1985-01-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 127-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Mapping Electric Stimulation Male Medulla Oblongata / physiopathology* Mesencephalon / physiopathology* Pain / physiopathology* Periaqueductal Gray / physiopathology Rats Rats, Inbred Strains Tegmentum Mesencephali / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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DA 01949/DA/NIDA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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