Document Detail


Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.
MedLine Citation:
PMID:  19645057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have reported an increased risk to develop Parkinson's disease (PD) in patients with idiopathic RBD (iRBD). Midbrain hyperechogenicity is a common transcranial sonography (TCS) finding in PD and has been suggested as a PD risk-marker in nonparkinsonian subjects. The objective of this study is to assess midbrain echogenicity by TCS in patients with iRBD and compare the findings with the healthy controls. TCS was performed in 55 iRBD patients and in 165 age and sex-matched controls. The area of echogenicity in the SN region in the iRBD group was significantly increased compared with the control group (P < 0.001). About 19 (37.3%) of patients with iRBD were found to have SN hyperechogenicity when compared with 16 (10.7%) of the controls (P < 0.001). This is the first case-control study assessing midbrain echogenicity in a large iRBD cohort compared to age- and sex-matched healthy individuals. The finding of an increased prevalence of hyperechogenicity in a subgroup of individuals with a priori increased risk for PD supports the potential role of hyperechogenicity as a risk marker for PD. The prospective follow-up of this iRBD cohort is needed to establish if those with midbrain hyperechogenicity will go on to develop clinically defined PD or not.
Authors:
Heike Stockner; Alex Iranzo; Klaus Seppi; M??nica Serradell; Viola Gschliesser; Martin Sojer; Francesc Valldeoriola; Jos?? L Molinuevo; Birgit Frauscher; Christof Schmidauer; Joan Santamaria; Birgit H??gl; Eduardo Tolosa; Werner Poewe;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-03     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1906-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Medical University Innsbruck, Innsbruck 6020, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Cohort Studies
Cross-Cultural Comparison
Female
Humans
International Cooperation
Male
Mesencephalon / pathology*,  ultrasonography*
Middle Aged
Parkinson Disease / etiology*,  ultrasonography
Psychiatric Status Rating Scales
REM Sleep Behavior Disorder* / complications,  pathology,  ultrasonography
Ultrasonography, Doppler, Transcranial / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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