| Midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release. | |
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MedLine Citation:
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PMID: 18521007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study determined the role of ventral tegmental area acetylcholine and glutamate receptors in modulating laterodorsal tegmentum stimulation-evoked dopamine efflux in the nucleus accumbens. Rapid changes in dopamine oxidation current were measured at carbon fiber microelectrodes using fixed potential amperometry in urethane anesthetized male mice. Intraventral tegmental area infusions of the muscarinic acetylcholine receptor antagonist scopolamine, the nicotinic acetylcholine receptor antagonist mecamylamine, or the ionotropic glutamate receptor antagonist kynurenate significantly diminished dopamine efflux in the nucleus accumbens evoked by brief electrical stimulation of the laterodorsal tegmentum. These findings suggest that acetylcholine and ionotropic glutamate receptors influence rapid dopaminergic activity and thus the communication of behaviorally relevant information from ventral tegmental area dopamine cells to forebrain areas. |
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Authors:
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Deranda B Lester; Anthony D Miller; Tiffany D Pate; Charles D Blaha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroreport Volume: 19 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-03 Completed Date: 2008-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 991-5 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Memphis, Memphis, Tennessee 38152-6400, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholinergic Antagonists / pharmacology Dopamine / metabolism* Electric Stimulation / methods Electrochemistry / methods Excitatory Amino Acid Antagonists / pharmacology Kynurenic Acid / pharmacology Male Mecamylamine / pharmacology Mesencephalon / metabolism* Mice Mice, Inbred C57BL Nucleus Accumbens / metabolism* Receptors, Cholinergic / physiology* Receptors, Glutamate / physiology* Scopolamine / pharmacology Ventral Tegmental Area / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cholinergic Antagonists; 0/Excitatory Amino Acid Antagonists; 0/Receptors, Cholinergic; 0/Receptors, Glutamate; 492-27-3/Kynurenic Acid; 51-34-3/Scopolamine; 60-40-2/Mecamylamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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