Document Detail


Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger.
MedLine Citation:
PMID:  23064394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is now widespread agreement that individual variation in the neural circuits representing the reinforcing properties of foods may be associated with risk for overeating and obesity. What is currently unknown is how and whether brain response to a food is related to immediate subsequent intake of that food. Here we used functional magnetic resonance imaging (fMRI) to test whether response to a palatable milkshake is associated with subsequent ad libitum milkshake consumption. We predicted that enhanced responses in key reward regions (insula, striatum, midbrain, medial orbitofrontal cortex) and decreased responses in regions implicated in self-control (lateral prefrontal and lateral orbitofrontal cortex) would be associated with greater intake. We found a significant positive association between response to milkshake in the periaqueductal gray region of the midbrain and ad libitum milkshake intake. Although strong bilateral insular responses were observed during consumption of the milkshake this response did not correlate with subsequent intake. The associations observed in the midbrain and orbitofrontal cortex were uninfluenced by ratings of hunger, which were near neutral. We conclude that midbrain response to a palatable food is related to eating in the absence of hunger.
Authors:
Sarah Nolan-Poupart; Maria G Veldhuizen; Paul Geha; Dana M Small
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-12
Journal Detail:
Title:  Appetite     Volume:  60     ISSN:  1095-8304     ISO Abbreviation:  Appetite     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-09     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  168-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Beverages
Body Mass Index
Cerebral Cortex / physiology
Corpus Striatum / physiology
Eating / physiology
Energy Intake*
Female
Humans
Hunger / physiology*
Hyperphagia
Magnetic Resonance Imaging
Male
Mesencephalon / physiology*
Obesity
Questionnaires
Reward
Risk Factors
Taste / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
R01 DK085579/DK/NIDDK NIH HHS; R01K085579//PHS HHS
Chemical
Reg. No./Substance:
E78ZFF4KQ0/Reward
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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