Document Detail

Midbrain and Falx in Fetuses with Absent Corpus Callosum at 11-13 Weeks.
MedLine Citation:
PMID:  22854275     Owner:  NLM     Status:  Publisher    
Objective: To describe the first trimester diagnosis of agenesis of the corpus callosum (ACC). Methods: The midbrain and falx cerebri were examined in stored images of the midsagittal view of the fetal brain at 11(+0)-13(+6) weeks' gestation from 15 fetuses with ACC and 500 normal controls. The midbrain diameter and falx diameter were measured and their ratio was calculated. The values in fetuses with ACC and normal controls were compared. Results: In the control group, the midbrain and falx diameters increased significantly with crown-rump length (CRL) from respective mean values of 5.1 and 6.9 mm at CRL of 45-6.9 mm and 12.1 mm at CRL of 84 mm. In the ACC group the midbrain diameter was above the 95th percentile of the control group in 8 (53.3%) cases, the falx diameter was below the 5th percentile in 6 (40.0%) cases and the midbrain diameter-to-falx diameter ratio was above the 95th percentile in 13 (86.7%) cases. Conclusions: In the midsagittal view of the fetal brain at 11-13 weeks, the majority of fetuses with ACC have measurable abnormalities in the midbrain and falx area of the brain.
Robert Lachmann; Danielle Sodre; Michail Barmpas; Ranjit Akolekar; Kypros H Nicolaides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-31
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  -     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, University Hospital Carl Gustav Carus, Dresden, Germany.
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