| Midbrain cleft as a cause of chronic internuclear ophthalmoplegia, progressive ataxia, and facial weakness. | |
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MedLine Citation:
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PMID: 20393349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 44-year-old man with progressive ataxia, facial weakness, bilateral adduction deficits, and abducting nystagmus was initially misdiagnosed and treated for multiple sclerosis because a midbrain anatomic cleft had been overlooked on brain MRI. Six cases of "midbrain (or mesencephalic) cleft" or "keyhole aqueduct syndrome" have been previously reported. This developmental anatomic abnormality always manifests bilateral internuclear ophthalmoplegia (INO), often together with ataxia, which may be progressive and debilitating. Because the INO is chronic, patients may have no visual symptoms. The cause of a midbrain cleft is uncertain, but it may be the midbrain version of a syrinx. There is no known effective treatment. |
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Authors:
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Omar Ahmad; Stephen Reddel; Christian J Lueck |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Volume: 30 ISSN: 1536-5166 ISO Abbreviation: J Neuroophthalmol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431308 Medline TA: J Neuroophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 145-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, The Canberra Hospital and Australian National University Medical School, Canberra, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ataxia / etiology* Cerebral Aqueduct / abnormalities, pathology*, physiopathology Chronic Disease Diagnosis, Differential Disease Progression Facial Nerve Diseases / etiology* Humans Magnetic Resonance Imaging Male Mesencephalon / abnormalities, pathology*, physiopathology Multiple Sclerosis / diagnosis, physiopathology Nervous System Malformations / complications, pathology*, physiopathology Neural Pathways / pathology, physiopathology Ocular Motility Disorders / etiology* Syringomyelia / pathology, physiopathology |
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