Document Detail


Midazolam for treatment of refractory neonatal seizures. A case report.
MedLine Citation:
PMID:  7826258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Midazolam is a short-acting water soluble benzodiazepine that has been used with an increasing frequency in the last years. Although there are reports on its use in status epilepticus, there is none in the neonatal period. A pre-term (35 w) AGA newborn infant with a severe hypoxic-ischemic encephalopathy secondary to grade III hyaline membrane disease developed status epilepticus in the first 6 hours of life and was successfully treated with midazolam after phenobarbital and phenytoin failed to achieve seizure control. Dosage schedule was 0.2 mg/kg IV, followed by continuous infusion of 0.025 mg/kg/h. Midazolam is an effective drug for neonatal status epilepticus and more experience should accumulate before it can be routinely employed in the neonatal period. This case shows that it is a possible option before using more dangerous drugs, such as thionembutal.
Authors:
J L Gherpelli; F J Luccas; I Roitman; E J Troster
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  52     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1995-02-14     Completed Date:  1995-02-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  260-2     Citation Subset:  IM    
Affiliation:
Hospital Israelita Albert Einstein, São Paulo, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Humans
Infant, Newborn
Infant, Premature
Male
Midazolam / therapeutic use*
Ovum
Status Epilepticus / drug therapy*
Chemical
Reg. No./Substance:
59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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