| Midazolam for treatment of refractory neonatal seizures. A case report. | |
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MedLine Citation:
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PMID: 7826258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Midazolam is a short-acting water soluble benzodiazepine that has been used with an increasing frequency in the last years. Although there are reports on its use in status epilepticus, there is none in the neonatal period. A pre-term (35 w) AGA newborn infant with a severe hypoxic-ischemic encephalopathy secondary to grade III hyaline membrane disease developed status epilepticus in the first 6 hours of life and was successfully treated with midazolam after phenobarbital and phenytoin failed to achieve seizure control. Dosage schedule was 0.2 mg/kg IV, followed by continuous infusion of 0.025 mg/kg/h. Midazolam is an effective drug for neonatal status epilepticus and more experience should accumulate before it can be routinely employed in the neonatal period. This case shows that it is a possible option before using more dangerous drugs, such as thionembutal. |
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Authors:
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J L Gherpelli; F J Luccas; I Roitman; E J Troster |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Arquivos de neuro-psiquiatria Volume: 52 ISSN: 0004-282X ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1995-02-14 Completed Date: 1995-02-14 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 260-2 Citation Subset: IM |
Affiliation:
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Hospital Israelita Albert Einstein, São Paulo, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Infant, Newborn Infant, Premature Male Midazolam / therapeutic use* Ovum Status Epilepticus / drug therapy* |
| Chemical | |
Reg. No./Substance:
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59467-70-8/Midazolam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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