Document Detail

Midazolam for prolonged intravenous sedation in patients with tetanus.
MedLine Citation:
PMID:  8413057     Owner:  NLM     Status:  MEDLINE    
Midazolam was used for prolonged sedation in ten adult patients with severe tetanus in the Intensive Care Unit for periods ranging from 10 to 50 days. An infusion was started soon after induction and adjusted according to clinical needs. All the patients were intubated and ventilated and in addition received morphine 1-2 mg/hr and alcuronium or pancuronium infusion. Two patients died from complications of tetanus. Six patients recovered from the effects of midazolam within 24 hrs of the cessation of infusion. Recovery took 48 and 72 hrs respectively in the other two patients. Midazolam is a suitable drug for long-term sedation in patients with tetanus. However, dose requirements are variable and recovery may be delayed in some patients.
H K Gyasi; J Fahr; E Kurian; M Mathew
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Middle East journal of anaesthesiology     Volume:  12     ISSN:  0544-0440     ISO Abbreviation:  Middle East J Anaesthesiol     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-11-05     Completed Date:  1993-11-05     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  8604187     Medline TA:  Middle East J Anaesthesiol     Country:  LEBANON    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Infusions, Intravenous
Midazolam / administration & dosage*
Middle Aged
Tetanus / drug therapy*
Time Factors
Reg. No./Substance:

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