Document Detail

Midazolam: pharmacology and uses.
MedLine Citation:
PMID:  3156545     Owner:  NLM     Status:  MEDLINE    
Midazolam is an imidazobenzodiazepine with unique properties when compared with other benzodiazepines. It is water soluble in its acid formulation but is highly lipid soluble in vivo. Midazolam also has a relatively rapid onset of action and high metabolic clearance when compared with other benzodiazepines. The drug produces reliable hypnosis, amnesia, and antianxiety effects when administered orally, intramuscularly, or intravenously. There are many uses for midazolam in the perioperative period including premedication, anesthesia induction and maintenance, and sedation for diagnostic and therapeutic procedures. Midazolam is preferable to diazepam in many clinical situations because of its rapid, nonpainful induction and lack of venous irritation. Compared with thiopental, midazolam is not as rapid acting nor predictable in hypnotic effect. It will not replace thiopental as an induction agent. Advantages of midazolam over thiopental are those of the more versatile pharmacologic properties of a benzodiazepine compared with a barbiturate such as amnestic and anxiolytic properties. Midazolam should be a useful addition to the formulary.
J G Reves; R J Fragen; H R Vinik; D J Greenblatt
Related Documents :
6444945 - Methyl-coenzyme m, an intermediate in methanogenic dissimilation of c1 compounds by met...
8857665 - Chemical characterization of melanins in sheep wool and human hair.
2165905 - The quaternary structure of escherichia coli inorganic pyrophosphatase is essential for...
3156545 - Midazolam: pharmacology and uses.
3989495 - Amino acids can induce nondisjunction during maturation of mammalian oocytes in vitro.
15213185 - Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interacti...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anesthesiology     Volume:  62     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-12     Completed Date:  1985-04-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  310-24     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ambulatory Surgical Procedures
Benzodiazepines / administration & dosage,  adverse effects,  antagonists & inhibitors,  metabolism,  pharmacology*
Benzodiazepinones / pharmacology
Brain / drug effects
Chemical Phenomena
Hemodynamics / drug effects
Hypnotics and Sedatives*
Hypoxia, Brain / prevention & control
Injections, Intravenous
Middle Aged
Nausea / chemically induced
Preanesthetic Medication*
Respiration / drug effects
Sex Factors
Thrombophlebitis / chemically induced
Reg. No./Substance:
0/Anesthetics; 0/Benzodiazepinones; 0/Hypnotics and Sedatives; 12794-10-4/Benzodiazepines; 59467-70-8/Midazolam; 78755-81-4/Flumazenil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical comparison of atracurium and alcuronium in gynaecological surgery.
Next Document:  Ia-like antigens on T-cells and their subpopulations in pulmonary sarcoidosis and in hypersensitivit...