|Midazolam: pharmacology and uses.|
|PMID: 3156545 Owner: NLM Status: MEDLINE|
|Midazolam is an imidazobenzodiazepine with unique properties when compared with other benzodiazepines. It is water soluble in its acid formulation but is highly lipid soluble in vivo. Midazolam also has a relatively rapid onset of action and high metabolic clearance when compared with other benzodiazepines. The drug produces reliable hypnosis, amnesia, and antianxiety effects when administered orally, intramuscularly, or intravenously. There are many uses for midazolam in the perioperative period including premedication, anesthesia induction and maintenance, and sedation for diagnostic and therapeutic procedures. Midazolam is preferable to diazepam in many clinical situations because of its rapid, nonpainful induction and lack of venous irritation. Compared with thiopental, midazolam is not as rapid acting nor predictable in hypnotic effect. It will not replace thiopental as an induction agent. Advantages of midazolam over thiopental are those of the more versatile pharmacologic properties of a benzodiazepine compared with a barbiturate such as amnestic and anxiolytic properties. Midazolam should be a useful addition to the formulary.|
|J G Reves; R J Fragen; H R Vinik; D J Greenblatt|
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|Type: Journal Article; Review|
|Title: Anesthesiology Volume: 62 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1985 Mar|
|Created Date: 1985-04-12 Completed Date: 1985-04-12 Revised Date: 2008-11-21|
Medline Journal Info:
|Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES|
|Languages: eng Pagination: 310-24 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Ambulatory Surgical Procedures
Benzodiazepines / administration & dosage, adverse effects, antagonists & inhibitors, metabolism, pharmacology*
Benzodiazepinones / pharmacology
Brain / drug effects
Hemodynamics / drug effects
Hypnotics and Sedatives*
Hypoxia, Brain / prevention & control
Nausea / chemically induced
Respiration / drug effects
Thrombophlebitis / chemically induced
|0/Anesthetics; 0/Benzodiazepinones; 0/Hypnotics and Sedatives; 12794-10-4/Benzodiazepines; 59467-70-8/Midazolam; 78755-81-4/Flumazenil|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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