| Midazolam inhibits cardiac nociception evoked by coronary artery occlusion in rats. | |
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MedLine Citation:
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PMID: 18289449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: This study was designed to investigate the potential existence of the response of neurons in the parafascicular nucleus of the thalamus to acute myocardial ischaemia induced by selective coronary artery occlusion and the effects of midazolam on the response in rats. METHODS: The left anterior descending branch of the coronary artery was instrumented with a snare occluder in anaesthetized Sprague-Dawley rats. A single-barrel glass microelectrode was used for recording the unit discharges of the neuron in the parafascicular nucleus. The neuron responding only to noxious somatic stimulation was further examined for the response to coronary artery occlusion. Once the effect of coronary artery occlusion on the discharges was detected, the pharmacological effects of midazolam and flumazenil were examined. RESULTS: It was observed that the discharge rate of the neuron was markedly increased following coronary artery occlusion. Midazolam attenuated the increase in the discharges of the neuron induced by coronary artery occlusion (P < 0.05). The effect of midazolam was reversed by flumazenil. CONCLUSIONS: The parafascicular nucleus is involved in the modulation of cardiac nociception and midazolam possesses antinociceptive property in modulating cardiac pain. |
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Authors:
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Z Guo; D-J Yuan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-21 |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 25 ISSN: 1365-2346 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-01 Completed Date: 2008-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: England |
Other Details:
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Languages: eng Pagination: 479-84 Citation Subset: IM |
Affiliation:
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Shanxi Medical University and Second Hospital of Shanxi Medical University, Department of Anesthesiology, Taiyuan, Shanxi, PR China. ykdgz2004@yahoo.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Intravenous
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therapeutic use* Animals Constriction Coronary Vessels* Intralaminar Thalamic Nuclei / cytology, drug effects*, physiology Male Midazolam / therapeutic use* Neurons / drug effects*, physiology Nociceptors / drug effects, physiology Pain Measurement Random Allocation Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 59467-70-8/Midazolam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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