Document Detail


Midazolam for induction of anaesthesia in patients with limited cardiac reserves. A comparison with etomidate.
MedLine Citation:
PMID:  3340909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The new water-soluble benzodiazepine, midazolam (Dormicum; Roche), was compared with etomidate as part of a balanced technique for induction of anaesthesia in 16 patients undergoing cardiac valve replacement. Monitoring revealed a significantly greater fall in blood pressure in patients receiving midazolam (reaching dangerous levels in 2 patients), which suggests that this agent is not suitable for induction of anaesthesia in haemodynamically compromised patients.
Authors:
R G MacGillivray; D A Rocke; A E Mahomedy
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  73     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-03-14     Completed Date:  1988-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  101-3     Citation Subset:  IM    
Affiliation:
Department of Anaesthetics, University of Natal, Durban.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, General / methods*
Blood Pressure / drug effects*
Etomidate / pharmacology*
Female
Heart Rate / drug effects*
Heart Valves / transplantation
Humans
Male
Midazolam / pharmacology*
Random Allocation
Time Factors
Chemical
Reg. No./Substance:
33125-97-2/Etomidate; 59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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