Document Detail

Mid-trimester maternal heart rate is related to neonatal birth weight.
MedLine Citation:
PMID:  23342989     Owner:  NLM     Status:  Publisher    
Abstract Objective(s): We sought to establish the relationship between maternal mid- trimester heart rate and neonatal birth weight in women at high a priori risk of preeclampsia. Study Design: 99 women were recruited following second trimester uterine artery Doppler assessment. Maternal blood pressure (BP) and heart rate (HR) were measured between 23(+4)-30(+5) weeks gestation and neonatal birth weight was expressed as a z-score. The relationship between the parameters was investigated using Pearson's correlation coefficient. Results: There was a significant positive correlation between maternal HR and neonatal birth weight z-score, r = 0.22 (95% CI: 0.02-0.40), P = 0.03. An inverse correlation was found between uterine artery Doppler PI and maternal HR r = -0.43 (95%CI: 0.01-0.40), P = 0.0001 and neonatal birth weight, r = -0.3 (95%CI: -0.47- -0.10), P = 0.004. For neonatal birth weight z-score < -1.65, r = 0.69 (95%CI 0.15-0.91) P = 0.02. There was no relationship between BP and uterine artery Doppler or neonatal birth weight. Conclusion: The finding of a continuous relationship between maternal heart rate and neonatal birth weight prior to the onset of fetal growth restriction, is novel, suggesting that maternal cardiovascular adaptation is reflected by neonatal birth weight. Lower maternal heart rate is associated with lower neonatal birth weight and vice versa. Further, we confirm the reported associations between uterine artery Doppler PI and both maternal HR and neonatal birth weight.
Thomas R Everett; Amita A Mahendru; Carmel M McEniery; Ian B Wilkinson; Christoph C Lees
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Dept of Fetal Medicine, Box 228, Rosie Hospital, Cambridge University Hospitals NHS Trust, Cambridge, CB2 2SW, UK.
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