Document Detail

Mid-trimester amniotic fluid methionine concentrations: a predictor of birth weight and length.
MedLine Citation:
PMID:  16919537     Owner:  NLM     Status:  MEDLINE    
The association between body size at birth and risk of later cardiovascular disease is thought to be a consequence of metabolic changes that accompany slow growth in utero. The metabolism of methionine and homocysteine has been investigated in relation to cardiovascular risk and has also been assigned an important role in organogenesis and normal fetal growth. We determined concentrations of cobalamin, folate, methionine, cysteine, cystathionine, and the marker of B-vitamin function, homocysteine, in 625 samples of amniotic fluid obtained in the second trimester from normal pregnancies. Both vitamins and metabolites varied according to gestational age. The most noticeable observation was that methionine in amniotic fluid during gestational weeks 13 to 17 strongly predicted final birth weight and length. Metabolism of methionine may be a critical factor affecting fetal growth.
Anne-Lise Bjørke Monsen; Jørn Schneede; Per Magne Ueland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  55     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1186-91     Citation Subset:  IM    
Institute of Medicine, Section for Pharmacology, University of Bergen, N-5021 Bergen, Norway.
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MeSH Terms
Amniotic Fluid / chemistry*
Birth Weight
Body Height
Body Size*
Fetal Development
Folic Acid / analysis
Infant, Newborn
Methionine / analysis*,  metabolism
Predictive Value of Tests*
Pregnancy Trimester, Second / metabolism*
Vitamin B 12 / analysis
Reg. No./Substance:
59-30-3/Folic Acid; 63-68-3/Methionine; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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