Document Detail

Mid-term results of self-testing of the international normalized ratio in adults with a mechanical heart valve.
MedLine Citation:
PMID:  24112749     Owner:  NLM     Status:  Publisher    
BACKGROUND: Commonly the frequency of international normalized ratio (INR) monitoring with a conventional laboratory test in stable patients is once a month. When using a dedicated personal device for INR assessment, the frequency may be increased to two or more times a month.
OBJECTIVE: To show that INR assessed by self-measurement at home is reliable and feasible in the mid-term and improves medical care.
PATIENTS AND METHODS: All patients in the study on INR self-measurement (clinical NCT00925197), conducted between 2004 and 2007, were re-contacted for mid-term follow-up. One hundred and seventy eight out of 192 patients who participated in the study answered a questionnaire. The average follow-up time was 4.2years (±1) for the self-measurement group and 4.9years (±1) for the laboratory-analyzed control group.
RESULTS: Only 26 patients (group A) continued to use INR self-measurement to monitor treatment with vitamin K antagonists (VKA). The main reasons to stop INR self-measurement were its high cost and difficulty in obtaining strips. There were significantly fewer bleeding complications (p=0.04) and complications related to VKA (p=0.01) in self-measured patients compared to the control group. Feelings of security and quality of life were also significantly better (p=0.002) for self-measured patients.
CONCLUSION: Many patients with a mechanical heart valve, who self-measured INR, continue to use this method for their follow-up because of its positive effects on their health and quality of life.
Kasra Azarnoush; Enrica Dorigo; Bruno Pereira; Claire Dauphin; Etienne Geoffroy; Nicolas Dauphin; Nicola D'Ostrevy; Benoit Legault; Lionel Camilleri
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-16
Journal Detail:
Title:  Thrombosis research     Volume:  -     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Elsevier Ltd. All rights reserved.
Heart surgery Department, G. Montpied Hospital, Clermont-Ferrand University Hospital, Clermont-Ferrand, France. Electronic address:
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