Document Detail

Mid-term angiographic benefit of sirolimus-eluting stents compared with paclitaxel-eluting stents in patients with acute myocardial infarction.
MedLine Citation:
PMID:  19632525     Owner:  NLM     Status:  In-Process    
BACKGROUND: We compared angiographic and clinical outcomes among different drug-eluting stents (DESs) in Korean acute myocardial infarction (AMI) patients.
METHODS: A total of 109 consecutive AMI patients who underwent percutaneous coronary intervention (PCI) with either sirolimus-eluting (SES, n=56 pts) or paclitaxel-eluting stents (PES, n=53 pts) were enrolled from August 2004 to December 2006. The angiographic outcomes at 6 months and clinical outcomes at 1 year were compared between the two groups.
RESULTS: Baseline clinical and procedural characteristics were similar between the two groups. At 6 months, the rate of binary restenosis was 17.0% in the PES group compared with 3.6% in the SES group (p=0.026). Percent restenosis was 24.9+/-28.6% in the PES group compared with 11.2+/-17.6% in the SES group (p=0.004). Length of restenosis segment was 3.21+/-9.02 mm in the PES group compared with 0.89+/-2.38 mm in the SES group (p=0.048). Late loss was 0.73+/-0.89 mm in the PES group compared with 0.28+/-0.37 mm in the SES group (p=0.001). However, there were no differences in clinical outcomes at 1 year including mortality, myocardial infarction, repeat PCI, and major cardiac adverse events between two groups.
CONCLUSION: SES implantation in patients with AMI was associated with reduction in angiographic restenosis at 6 months compared with PES, however, these angiographic benefits were not translated into better clinical outcomes in real world clinical practice.
Cheol Ung Choi; Seung-Woon Rha; Kang-Yin Chen; Zhe Jin; Yoshiyasu Minami; Seung Yong Shin; Jin Oh Na; Soon Yong Suh; Hong Euy Lim; Jin Won Kim; Eung Ju Kim; Chang Gyu Park; Hong Seog Seo; Dong Joo Oh
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Publication Detail:
Type:  Journal Article     Date:  2009-05-28
Journal Detail:
Title:  Journal of cardiology     Volume:  54     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  80-5     Citation Subset:  IM    
Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
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