Document Detail

Mid-second trimester organic acids in severe open neural tube defects.
MedLine Citation:
PMID:  8542473     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate amnioic fluid organic concentrations at 16 weeks gestation from normal fetuses and those affected by severe neural tube defects. METHODS: Amniotic fluid collected from normal, anencephalic and severe open spina bifida fetuses was analysed for up to 24 organic acids by gas liquid chromatography. RESULTS: Significant increase in organic acids similar to those observed in defects of phenylalanine and tyrosine metabolism were identified when compared with the normal fetuses. Significant differences in organic acid concentrations were also identified within the two neural tube defect groups. CONCLUSION: A relationship between phenylalanine and tyrosine metabolism, closure rate of the neural tube and folate metabolism is proposed.
M Legge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology (Tokyo, Japan)     Volume:  21     ISSN:  1340-9654     ISO Abbreviation:  J Obstet Gynaecol (Tokyo 1995)     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-02-13     Completed Date:  1996-02-13     Revised Date:  2009-07-30    
Medline Journal Info:
Nlm Unique ID:  9515066     Medline TA:  J Obstet Gynaecol (Tokyo 1995)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  483-7     Citation Subset:  IM    
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
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MeSH Terms
Amniotic Fluid / chemistry*
Anencephaly / metabolism*
Hydrolases / metabolism
Phenylalanine / metabolism
Pregnancy Trimester, Second
Spinal Dysraphism / metabolism*
Tyrosine / metabolism
Reg. No./Substance:
55520-40-6/Tyrosine; 63-91-2/Phenylalanine; EC 3.-/Hydrolases

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