Document Detail

Mid-pregnancy maternal plasma levels of interleukin 2, 6, and 12, tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor and spontaneous preterm delivery.
MedLine Citation:
PMID:  17712652     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Few studies have investigated the relationship between inflammation and spontaneous preterm delivery (sPTD) in women before preterm labour. The authors examine whether mid-pregnancy plasma cytokine levels are associated with sPTD, and whether associations vary by maternal age, body mass index, prior preterm delivery, or gravidity. METHODS: This case-control study was nested within the Danish National Birth Cohort, a cohort of women with 101,042 pregnancies from 1997 to 2002. Included in this study are 61 women delivering at 24-29 weeks, 278 delivering at 30-33 weeks, 334 delivering at 34-36 weeks, and 1,125 delivering at > or =37 weeks. Maternal plasma interleukin (IL)-2, IL-6, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and granulocyte-macrophage colony-stimulating factor (GM-CSF) at 25 weeks' gestation were measured using multiplex flow cytometry. RESULTS: For IL-2, TNF-alpha, and GM-CSF, the proportion of women with levels >75th or >90th percentile did not differ by gestational age at delivery. IFN-gamma >90th percentile was associated with an increased risk of delivering at 30-33 weeks (crude odds ratio (cOR): 1.56; 95% confidence interval (CI): 1.07-2.30), while IFN-gamma >75th percentile and IL-6 >75th percentile were associated with an increased risk of delivering at 34-36 weeks (cOR: 1.32; 95% CI: 1.01-1.73); estimates changed little after adjusting for confounders. There was no effect-measure modification by maternal factors. CONCLUSION: Elevated mid-pregnancy plasma IL-2, TNF-alpha, and GM-CSF did not appear to be associated with an increased risk of sPTD, while elevated IFN-gamma and IL-6 levels were weakly associated with moderate and late sPTD. The value of using mid-pregnancy cytokines in predicting spontaneous preterm delivery appears limited.
Allison E Curry; Ida Vogel; Carolyn Drews; Diana Schendel; Kristin Skogstrand; W Dana Flanders; David Hougaard; Jørn Olsen; Poul Thorsen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  86     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-11-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1103-10     Citation Subset:  IM    
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
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MeSH Terms
Biological Markers / blood
Body Mass Index
Case-Control Studies
Cohort Studies
Confidence Intervals
Denmark / epidemiology
Flow Cytometry
Gestational Age
Granulocyte-Macrophage Colony-Stimulating Factor / blood
Infant, Newborn
Infant, Premature
Interferon-gamma / blood*
Interleukin-12 / blood
Interleukin-2 / blood
Interleukin-6 / blood*
Obstetric Labor, Premature / blood*,  diagnosis*,  epidemiology
Odds Ratio
Predictive Value of Tests
Pregnancy Trimester, Second / blood*
Pregnancy Trimester, Third / blood
Time Factors
Tumor Necrosis Factor-alpha / blood
Grant Support
UR3/CCU018305-03//PHS HHS
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-2; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 187348-17-0/Interleukin-12; 82115-62-6/Interferon-gamma; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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