Document Detail


Mid-pregnancy levels of angiogenic markers as indicators of pathways to preterm delivery.
MedLine Citation:
PMID:  21939291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether mid-pregnancy levels of angiogenic markers were associated with increased risk of preterm delivery (PTD).
METHODS: We studied a subcohort from the Pregnancy Outcomes and Community Health Study for whom mid-pregnancy angiogenic markers (soluble fms-like tyrosine kinase-1 [sFlt-1], soluble endoglin [sEng] and placental growth factor [PlGF]) and covariate data were available (N = 1301). Angiogenic marker levels were grouped as high/not high (sFlt-1 and sEng), low/not low (PlGF) and high/intermediate/low (sFlt-1). Associations between levels of angiogenic markers and PTD/PTD subtype were determined for women who were nonsmokers during pregnancy (N = 933).
RESULTS: Low PlGF and high sEng were associated with medically-indicated PTD and PTD <35 weeks, largely due to preeclampsia (PE). Excluding PE and small-for-gestational-age infants, low sFlt-1 was positively associated with medically-indicated PTD.
CONCLUSIONS: Among nonsmokers, mid-pregnancy levels of angiogenic markers may mark multiple pathways leading to PTD, only one attributable to PE.
Authors:
Renée S Mijal; Claudia B Holzman; Sarosh Rana; S Ananth Karumanchi; Jianling Wang; Alla Sikorskii
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2011-10-24
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-26     Completed Date:  2012-11-21     Revised Date:  2014-09-03    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1135-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / blood*
Biological Markers / blood
Female
Humans
Infant, Newborn
Infant, Small for Gestational Age
Neovascularization, Physiologic
Pre-Eclampsia / blood
Pregnancy
Pregnancy Proteins / blood*
Pregnancy Trimester, Second
Premature Birth / blood*
Receptors, Cell Surface / blood*
Vascular Endothelial Growth Factor Receptor-1 / blood*
Young Adult
Grant Support
ID/Acronym/Agency:
R01 HD034543/HD/NICHD NIH HHS; R01 HD34543/HD/NICHD NIH HHS; T32 HD046377/HD/NICHD NIH HHS; T32 HD046377/HD/NICHD NIH HHS; U01 DP000143-01/DP/NCCDPHP CDC HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Biological Markers; 0/ENG protein, human; 0/Pregnancy Proteins; 0/Receptors, Cell Surface; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1
Comments/Corrections

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