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Mid-pregnancy levels of angiogenic markers as indicators of pathways to preterm delivery.
MedLine Citation:
PMID:  21939291     Owner:  NLM     Status:  Publisher    
Abstract Objective: To determine if midpregnancy levels of angiogenic markers were associated with increased risk of preterm delivery (PTD). Methods: We studied a subcohort from the Pregnancy Outcomes and Community Health Study for whom midpregnancyangiogenic markers [(soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng), and placental growth factor (PlGF)], and covariate data were available (N = 1301). Angiogenic marker levels were grouped as High/Not High (sFlt-1 &sEng), Low/Not Low (PlGF) and High/Intermediate/Low (sFlt-1). Associations between levels of angiogenic markers and PTD/PTD subtype were determined for women who were non-smokers during pregnancy (N=933). Results: Low PlGF and High sEng were associated with medically-indicated PTD and PTD <35 weeks, largely due to preeclampsia. Excluding preeclampsia and small-for-gestational-age infants, Low sFlt-1 was positively associated with medically-indicated PTD. Conclusions: Among non-smokers midpregnancy levels of angiogenic markers may mark multiple pathways leading to PTD, only one attributable to preeclampsia.
Renée S Mijal; Claudia B Holzman; Sarosh Rana; Ananth Karumanchi; Jianling Wang; Alla Sikorskii
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-22
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Epidemiology, Michigan State University, East Lansing, MI.
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