| Mid-pregnancy levels of angiogenic markers as indicators of pathways to preterm delivery. | |
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MedLine Citation:
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PMID: 21939291 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: To determine if midpregnancy levels of angiogenic markers were associated with increased risk of preterm delivery (PTD). Methods: We studied a subcohort from the Pregnancy Outcomes and Community Health Study for whom midpregnancyangiogenic markers [(soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng), and placental growth factor (PlGF)], and covariate data were available (N = 1301). Angiogenic marker levels were grouped as High/Not High (sFlt-1 &sEng), Low/Not Low (PlGF) and High/Intermediate/Low (sFlt-1). Associations between levels of angiogenic markers and PTD/PTD subtype were determined for women who were non-smokers during pregnancy (N=933). Results: Low PlGF and High sEng were associated with medically-indicated PTD and PTD <35 weeks, largely due to preeclampsia. Excluding preeclampsia and small-for-gestational-age infants, Low sFlt-1 was positively associated with medically-indicated PTD. Conclusions: Among non-smokers midpregnancy levels of angiogenic markers may mark multiple pathways leading to PTD, only one attributable to preeclampsia. |
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Authors:
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Renée S Mijal; Claudia B Holzman; Sarosh Rana; Ananth Karumanchi; Jianling Wang; Alla Sikorskii |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-22 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Epidemiology, Michigan State University, East Lansing, MI. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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