Document Detail


Mid-pregnancy circulating cytokine levels, histologic chorioamnionitis and spontaneous preterm birth.
MedLine Citation:
PMID:  18814919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some spontaneous preterm deliveries (PTD) are caused by occult infections of the fetal membranes (histologic chorioamnionitis [HCA]). High levels of infection-related markers, including some cytokines, sampled from maternal circulation in mid-pregnancy have been linked to PTD, but whether these specifically identify HCA has not been established. We have tested associations between 13 Th1, Th2 and Th17 cytokines and PTD with and without HCA in a prospective cohort study. The study sample included 926 Pregnancy Outcomes and Community Health Study subcohort women; women with medically indicated PTD or incomplete data excluded. A panel of cytokines was assessed using a multiplex assay in maternal plasma collected at 15-27 weeks of gestation. Severe HCA was scored by a placental pathologist blinded to clinical variables. Multivariable polytomous logistic regression was used to estimate adjusted odds ratios (OR) per 1 standard deviation (S.D.) increase in cytokine levels using a 5 level outcome variable: PTD <35 weeks with HCA, PTD <35 weeks without HCA, PTD 35-36 weeks with HCA, PTD 35-36 weeks without HCA, and term (referent). Interleukin (IL)-1beta, IL-2, IL-12, interferon-gamma, IL-4, IL-6 and transforming growth factor-beta were all significantly associated with PTD <35 weeks with HCA, with ORs of 1.6-2.3 per S.D. increase. None of these were associated with PTD <35 weeks without HCA or PTD 35-36 weeks with HCA. Although the tissues of origin of circulating cytokines are unclear, the observed elevations across many cytokines among women who later delivered <35 weeks with HCA may represent a robust immune response to infection within gestational tissues. These results suggest that women with HCA could be identified using relatively non-invasive means.
Authors:
Julia Warner Gargano; Claudia Holzman; Patricia Senagore; Poul Thorsen; Kristin Skogstrand; David M Hougaard; Mohammad H Rahbar; Hwan Chung
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2008-09-23
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  79     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-01-06     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  100-10     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, Michigan State University, B601 West Fee Hall, East Lansing, MI 48824, USA. jgargano@epi.msu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorioamnionitis / immunology*
Cohort Studies
Cytokines / blood*
Female
Humans
Logistic Models
Obstetric Labor, Premature / etiology*
Pregnancy
Grant Support
ID/Acronym/Agency:
R01 HD034543/HD/NICHD NIH HHS; R01 HD034543-03/HD/NICHD NIH HHS; R01 HD034543-04/HD/NICHD NIH HHS; R01 HD034543-05A1/HD/NICHD NIH HHS; R01 HD034543-06/HD/NICHD NIH HHS; R01 HD034543-07/HD/NICHD NIH HHS; R01 HD034543-07S1/HD/NICHD NIH HHS; R01 HD034543-08/HD/NICHD NIH HHS; R01 HD34543/HD/NICHD NIH HHS; U01 DP000143-01/DP/NCCDPHP CDC HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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