Document Detail

Mid-pregnancy androgen levels are negatively associated with breastfeeding.
MedLine Citation:
PMID:  19900072     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Breastfeeding depends on endocrine changes during pregnancy. The association between gestational hormones and lactation has been sparsely investigated. Previously, androgens were used for lactation inhibition. We investigated a possible association between second trimester maternal androgen levels and breastfeeding. DESIGN: Prospective observational study. SETTING: University hospital setting. POPULATION. Women from a random sample of pregnancies (n = 63) and from a group with an increased risk for giving birth to a small-for-gestational age newborn (n = 118) were included. All participants had singleton pregnancies and one or two previous births. METHODS: Maternal androgen levels were measured in gestational week 25. The association with reported breastfeeding was explored by univariate and multivariate linear regression analyses. Analyses were adjusted for factors known to be associated with breastfeeding. MAIN OUTCOME MEASURES: Breastfeeding at six weeks, three months, and six months postpartum. RESULTS: In the random group, breastfeeding at three and six months was negatively associated with maternal testosterone, androstendione, and free testosterone index levels. After correction for maternal age, education and smoking, breastfeeding at both three and six months was negatively associated with the free testosterone index. In the group of women with an increased risk for giving birth to a small-for-gestational age newborn, breastfeeding at six weeks and three months was associated negatively with maternal dehydroepiandrosterone and this association persisted after correction for maternal age, education, and smoking. CONCLUSIONS: Maternal androgen levels in mid-pregnancy are negatively associated with breastfeeding.
Sven Magnus Carlsen; Geir Jacobsen; Eszter Vanky
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  89     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-01-15     Revised Date:  2010-04-28    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
Unit of Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
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MeSH Terms
Androstenedione / blood*
Breast Feeding / statistics & numerical data*
Dehydroepiandrosterone / blood
Maternal Age
Multivariate Analysis
Pregnancy Trimester, Second / physiology*
Prospective Studies
Smoking / epidemiology
Socioeconomic Factors
Testosterone / blood*
Young Adult
Grant Support
Reg. No./Substance:
53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 63-05-8/Androstenedione
Comment In:
Acta Obstet Gynecol Scand. 2010 May;89(5):722-3; author reply 723-5   [PMID:  20205609 ]

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